Advanced Fetal Imaging - Phase II

NCT ID: NCT02840019

Last Updated: 2025-12-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

300 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-07-31

Study Completion Date

2028-06-30

Brief Summary

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The goal of Advanced Fetal Imaging - Phase II is to advance fetal MRI imaging by designing MRI coils specifically for pregnant women and testing recently developed MRI image acquisition techniques. The investigators aim to more reliably obtain higher quality fetal MRI images when compared to current clinical fetal MRI.

Detailed Description

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The main aim of this project is to evaluate and optimize the existing clinical magnetic resonance (MR) techniques for fetal imaging, and to also implement and test new MR technologies that would improve fetal imaging in general. This involves the development of new pulse sequences and image acquisition schemes that "freeze" fetal motion and hence provide improved image quality and robustness for both structural (T1- and T2- weighted, susceptibility and FLAIR imaging) and physiological imaging (diffusion, perfusion, spectroscopy, resting-state functional MRI, etc). The scope of this project also includes testing of newly developed radio frequency (RF) receive-only coil arrays that would inherently provide the means for faster imaging of the fetus, and thus complement the software developments.

Conditions

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Pregnancy

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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60 minute research full MRI scan

Pregnant women who are able to have an MRI are eligible for the 60 minute research full MRI scan. Pregnant women may have a healthy pregnancy, a concern for fetal/placental abnormalities with a clinical fetal MRI ordered by their doctor, or a concern for fetal/placental abnormalities without a clinical fetal MRI ordered by their doctor.

The investigational MRI coil designed for pregnant women and research MRI sequences will be tested during the 60 minute research scan.

Group Type EXPERIMENTAL

Investigational MRI coil designed for pregnant women

Intervention Type DEVICE

The investigational MRI receiver coil designed specifically for pregnant women will be used during the 60 minute full research MRI scan. An MRI receiver coil is part of the MRI machine that is placed over the body part being imaged during every MRI scan. A coil is required to obtain MR images, yet there isn't one designed for pregnant women. This investigational MRI receiver coil for pregnant women will be tested to see if it helps improve image quality and take images faster.

MRI Scan

Intervention Type PROCEDURE

All participants will participate in an MRI scan. The add-on MRI scan will be 15 minutes. The full MRI scan will be 60 minutes.

15 minute research add-on MRI scan

Pregnant women with a concern for fetal/placental abnormalities with a clinical fetal MRI at Boston Children's Hospital are eligible for the 15 minute research add-on MRI scan.

The research MRI sequences will also be tested during the add-on research MRI scan.

Group Type EXPERIMENTAL

MRI Scan

Intervention Type PROCEDURE

All participants will participate in an MRI scan. The add-on MRI scan will be 15 minutes. The full MRI scan will be 60 minutes.

Interventions

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Investigational MRI coil designed for pregnant women

The investigational MRI receiver coil designed specifically for pregnant women will be used during the 60 minute full research MRI scan. An MRI receiver coil is part of the MRI machine that is placed over the body part being imaged during every MRI scan. A coil is required to obtain MR images, yet there isn't one designed for pregnant women. This investigational MRI receiver coil for pregnant women will be tested to see if it helps improve image quality and take images faster.

Intervention Type DEVICE

MRI Scan

All participants will participate in an MRI scan. The add-on MRI scan will be 15 minutes. The full MRI scan will be 60 minutes.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* 60 Minute Full Research MRI Scan:

* Gestational age between 18 and 40 weeks

* AND
* Pregnant women with a healthy pregnancy

* OR
* Pregnant women with a concern for fetal/placental abnormalities referred for a clinical fetal MRI by their obstetrician

* OR
* Pregnant women with a concern for fetal/placental abnormalities NOT referred for a clinical fetal MRI by their obstetrician
* 15 Minute Add-On Research Scan:

* Gestational age between 18 and 40 weeks

* AND
* Pregnant women with a concern for fetal abnormalities referred for a clinical fetal MRI by their obstetrician

* AND
* The clinical fetal MRI will occur at Boston Children's Hospital

Exclusion Criteria

* Pregnant women with a contraindication to MRI (implanted metal, non-removable piercings, pacemaker, etc)
* Pregnant women who are claustrophobic
* Pregnant women who are medically unstable for an MRI
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Massachusetts Institute of Technology

OTHER

Sponsor Role collaborator

Massachusetts General Hospital

OTHER

Sponsor Role collaborator

Boston Children's Hospital

OTHER

Sponsor Role lead

Responsible Party

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Ellen Grant

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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P. Ellen Grant, MD

Role: PRINCIPAL_INVESTIGATOR

Boston Children's Hospital

Locations

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Boston Children's Hospital

Boston, Massachusetts, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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P. Ellen Grant, MD

Role: CONTACT

857-218-5111

Facility Contacts

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P. Ellen Grant, MD

Role: primary

857-218-5111

Other Identifiers

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R01EB017337

Identifier Type: NIH

Identifier Source: org_study_id

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