A Multi-Center Cohort Study of Risk Factors and Outcomes of Encephalopathy of Prematurity in China
NCT ID: NCT02831010
Last Updated: 2021-10-12
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
761 participants
OBSERVATIONAL
2014-04-30
2020-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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encephalopathy of prematurity
infants with encephalopathy of prematurity showed on MRI at term-equivalent age
No interventions assigned to this group
no encephalopathy of prematurity
infants with no encephalopathy of prematurity showed on MRI at term-equivalent age
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* chromosomal disorders
* metabolic diseases
28 Days
ALL
No
Sponsors
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Children's Hospital of Fudan University
OTHER
Responsible Party
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Principal Investigators
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Chao Chen, PhD, MD
Role: STUDY_DIRECTOR
Children's Hospital of Fudan University
Locations
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The First People's Hospital of Hefei
Hefei, Anhui, China
Xiamen Women's and Children's Health Centre
Xiamen, Fujian, China
People's Hospital of Zhangzhou
Zhangzhou, Fujian, China
The Second Affiliated Hospital of Guangzhou Medical University
Guangzhou, Guangdong, China
Zhongshan Bo Ai Hospital
Zhongshan, Guangdong, China
Maternal and Child Health Hospital of Guiyang Province
Guiyang, Guizhou, China
Handan Central Hospital
Handan, Hebei, China
First Hospital of Jilin University
Changchun, Jilin, China
Children's Hospital of Fudan University
Shanghai, Shanghai Municipality, China
Shanghai First Maternity and Infant Hospital
Shanghai, Shanghai Municipality, China
Shanxi Provincial Maternity and Children's Hospital
Xian, Shanxi, China
First Affiliated Hospital of Xinjiang Medical University
Ürümqi, Xinjiang, China
First Affiliated Hospital of Kunming Medical University
Kunming, Yunnan, China
Ningbo Women's and Children's Hospital
Ningbo, Zhejiang, China
Countries
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References
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Volpe JJ. Encephalopathy of prematurity includes neuronal abnormalities. Pediatrics. 2005 Jul;116(1):221-5. doi: 10.1542/peds.2005-0191. No abstract available.
Groenendaal F, Termote JU, van der Heide-Jalving M, van Haastert IC, de Vries LS. Complications affecting preterm neonates from 1991 to 2006: what have we gained? Acta Paediatr. 2010 Mar;99(3):354-8. doi: 10.1111/j.1651-2227.2009.01648.x. Epub 2010 Jan 8.
Volpe JJ. Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances. Lancet Neurol. 2009 Jan;8(1):110-24. doi: 10.1016/S1474-4422(08)70294-1.
Korzeniewski SJ, Romero R, Cortez J, Pappas A, Schwartz AG, Kim CJ, Kim JS, Kim YM, Yoon BH, Chaiworapongsa T, Hassan SS. A "multi-hit" model of neonatal white matter injury: cumulative contributions of chronic placental inflammation, acute fetal inflammation and postnatal inflammatory events. J Perinat Med. 2014 Nov;42(6):731-43. doi: 10.1515/jpm-2014-0250.
Sominsky L, Walker AK, Ong LK, Tynan RJ, Walker FR, Hodgson DM. Increased microglial activation in the rat brain following neonatal exposure to a bacterial mimetic. Behav Brain Res. 2012 Jan 1;226(1):351-6. doi: 10.1016/j.bbr.2011.08.038. Epub 2011 Sep 1.
Shatrov JG, Birch SCM, Lam LT, Quinlivan JA, McIntyre S, Mendz GL. Chorioamnionitis and cerebral palsy: a meta-analysis. Obstet Gynecol. 2010 Aug;116(2 Pt 1):387-392. doi: 10.1097/AOG.0b013e3181e90046.
Howson CP, Kinney MV, McDougall L, Lawn JE; Born Too Soon Preterm Birth Action Group. Born too soon: preterm birth matters. Reprod Health. 2013;10 Suppl 1(Suppl 1):S1. doi: 10.1186/1742-4755-10-S1-S1. Epub 2013 Nov 15.
Hendson L, Russell L, Robertson CM, Liang Y, Chen Y, Abdalla A, Lacaze-Masmonteil T. Neonatal and neurodevelopmental outcomes of very low birth weight infants with histologic chorioamnionitis. J Pediatr. 2011 Mar;158(3):397-402. doi: 10.1016/j.jpeds.2010.09.010. Epub 2010 Oct 18.
Sato M, Nishimaki S, Yokota S, Seki K, Horiguchi H, An H, Ishida F, Fujita S, Ao K, Yatake H. Severity of chorioamnionitis and neonatal outcome. J Obstet Gynaecol Res. 2011 Oct;37(10):1313-9. doi: 10.1111/j.1447-0756.2010.01519.x. Epub 2011 May 3.
Other Identifiers
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EKYYEOPMC
Identifier Type: -
Identifier Source: org_study_id
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