Potentially Inappropriate Prescription Associated to Multimorbidity
NCT ID: NCT02830425
Last Updated: 2020-04-09
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
740 participants
OBSERVATIONAL
2016-01-31
2019-12-31
Brief Summary
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Objectives:
1. To estimate and describe patterns of multimorbidity and polypharmacy in patients over 64 admitted for a chronic disease exacerbation.
2. To analyze the potentially inappropriate prescribing (PPI) drugs according to STOPP / START (SS) criteria.
3. To evaluate the relationship between multimorbidity and PPI and adverse medication (RAM) preventable reaction.
The cohort will include 800 patients \>64 years admitted in internal medicine and / or geriatric department of 5 hospitals of the National Health Service. Application of the SS criteria (released in 2015) on admission and at discharge, and collection of demographic and clinical variables including comorbidities, baseline chronic medication, geriatric syndromes, functional capacity and RAM. Descriptive analysis and bivariate parametric or nonparametric tests will be applied to analyze relationship between morbidity, polypharmacy, SS criteria and RAM. Intraobserver agreement will be assessed for SS criteria. Multiple regression techniques will be applied, where the dependent variable will be the PPI or the RAM.
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Interventions
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No intervention
Eligibility Criteria
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Inclusion Criteria
* Admitted to hospital because of an exacerbation of any previous chronic condition
Exclusion Criteria
* Patients with lower forecast life than 1 year
* Patient admitted to the hospital only because an acute problem
* In patient home care
65 Years
ALL
No
Sponsors
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Fondo de Investigacion Sanitaria
OTHER
Hospital del Mar
OTHER
Hospital de Galdakao
OTHER
Consorci Hospitalari de Vic
OTHER
Hospital Universitario de Canarias
OTHER
Corporacion Parc Tauli
OTHER
Responsible Party
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Marisa Baré, MD, MPH, PhD
Cancer Screening-Epidemiology Coordinator
Principal Investigators
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Marisa Baré, MD, MPH, PhD
Role: PRINCIPAL_INVESTIGATOR
Corporacio Parc Taulí
Locations
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Corporacio Parc Taulí
Sabadell, , Spain
Countries
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References
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Bare M, Herranz S, Jordana R, Gorgas MQ, Ortonobes S, Sevilla D, De Jaime E, Ibarra O, Martin C; MoPIM study group. Multimorbidity patterns in chronic older patients, potentially inappropriate prescribing and adverse drug reactions: protocol of the multicentre prospective cohort study MoPIM. BMJ Open. 2020 Jan 26;10(1):e033322. doi: 10.1136/bmjopen-2019-033322.
Ortonobes S, Herranz S, Lleal M, Sevilla-Sanchez D, Jordana R, Mascaro O, Ferrandez O, de Jaime E, Estrada R, Nazco GJ, Bare M; MoPIM Study Group. Multidisciplinary medication review during older patient hospitalization according to STOPP/START criteria reduces potentially inappropriate prescriptions: MoPIM cohort study. BMC Geriatr. 2024 Jul 8;24(1):584. doi: 10.1186/s12877-024-05185-w.
Lleal M, Bare M, Ortonobes S, Sevilla-Sanchez D, Jordana R, Herranz S, Gorgas MQ, Espaulella-Ferrer M, Arellano M, de Antonio M, Nazco GJ, Hernandez-Luis R, On Behalf Of The MoPIM Study Group. Comprehensive Multimorbidity Patterns in Older Patients Are Associated with Quality Indicators of Medication-MoPIM Cohort Study. Int J Environ Res Public Health. 2022 Nov 29;19(23):15902. doi: 10.3390/ijerph192315902.
Bare M, Lleal M, Ortonobes S, Gorgas MQ, Sevilla-Sanchez D, Carballo N, De Jaime E, Herranz S; MoPIM study group. Factors associated to potentially inappropriate prescribing in older patients according to STOPP/START criteria: MoPIM multicentre cohort study. BMC Geriatr. 2022 Jan 11;22(1):44. doi: 10.1186/s12877-021-02715-8.
Bare M, Herranz S, Roso-Llorach A, Jordana R, Violan C, Lleal M, Roura-Poch P, Arellano M, Estrada R, Nazco GJ; MoPIM study group. Multimorbidity patterns of chronic conditions and geriatric syndromes in older patients from the MoPIM multicentre cohort study. BMJ Open. 2021 Nov 15;11(11):e049334. doi: 10.1136/bmjopen-2021-049334.
Other Identifiers
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PI15/00552
Identifier Type: -
Identifier Source: org_study_id
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