Determinants of Vasospasm and Delayed Ischemic Deficits in Aneurysmal Subarachnoid Hemorrhage

NCT ID: NCT02829398

Last Updated: 2017-05-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

41 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-03-31

Study Completion Date

2011-10-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The risk of delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH) is associated with large cerebral artery vasospasm, but vasospasm is not a strong predictor for DCI. Assessment of cerebral autoregulation with transcranial Doppler (TCD) may improve the prediction of DCI. The aim of this prospective study was to assess the value of TCD-derived variables to be used alone or in combination for prediction of DCI

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Ischemia

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Patients with subarachnoid hemorrhage

Patients with subarachnoid hemorrhage will have CerebroSpinal fluid and plasma sample.

Group Type EXPERIMENTAL

CerebroSpinal fluid and plasma samples

Intervention Type PROCEDURE

CerebroSpinal fluid and plasma samples for biological markers

Control subjects

healthy controls from a previous study with a CerebroSpinal fluid and plasma sample

Group Type ACTIVE_COMPARATOR

CerebroSpinal fluid and plasma samples

Intervention Type PROCEDURE

CerebroSpinal fluid and plasma samples for biological markers

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

CerebroSpinal fluid and plasma samples

CerebroSpinal fluid and plasma samples for biological markers

Intervention Type PROCEDURE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

Group 1 : • Patients who presented a ruptured aneurysm by aneurysmal subarachnoid hemorrhage (SAH) older than 72 hours. Diagnosis of SAH was confirmed by computed tomography, magnetic resonance imaging (MRI) or lumbar puncture as recommended

* symptomatic aneurysm treated with endovascular,
* Absence of achieving a lumbar puncture,
* Patients affiliated to a social security scheme,
* Patients who have given their free and informed consent and signed the consent or consent of the family.

Group 2 :

healthy volunteers with cerebrospinal fluid sample

Exclusion Criteria

* Patients with no readable acoustic temporal bone window
* Patients with previous disease that might impair cerebral autoregulation (e.g., carotid stenosis, history of stroke or head injury).
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

University Hospital, Toulouse

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

LARRUE Vincent, MD

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Toulouse

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

University Hospital of Toulouse

Toulouse, , France

Site Status

Countries

Review the countries where the study has at least one active or historical site.

France

References

Explore related publications, articles, or registry entries linked to this study.

Calviere L, Nasr N, Arnaud C, Czosnyka M, Viguier A, Tissot B, Sol JC, Larrue V. Prediction of Delayed Cerebral Ischemia After Subarachnoid Hemorrhage Using Cerebral Blood Flow Velocities and Cerebral Autoregulation Assessment. Neurocrit Care. 2015 Oct;23(2):253-8. doi: 10.1007/s12028-015-0125-x.

Reference Type RESULT
PMID: 25716738 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

Local Grant

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

07 304 02

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.