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Computed Tomographic (CT) Perfusion and CT Angiography as Screening Tools for Vasospasm Following Subarachnoid Hemorrhage

NCT ID: NCT00962546

Last Updated: 2014-12-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

4 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-09-30

Study Completion Date

2011-12-31

Brief Summary

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Cerebral vasospasm is a devastating complication of subarachnoid hemorrhage after cerebral aneurysm rupture leading to cerebral ischemia and potentially cerebral infarction. The current gold standard diagnostic imaging study for cerebral vasospasm is catheter cerebral angiography, an invasive diagnostic procedure carrying a complication rate of 1-2% per procedure. Computed tomographic perfusion imaging (CTP) and computed tomographic angiography (CTA) are noninvasive diagnostic imaging studies frequently utilized in the evaluation of embolic and thrombotic cerebral infarct. The investigators hypothesize that CTP and CTA may be utilized as screening tools for cerebral vasospasm following aneurysmal subarachnoid hemorrhage requiring treatment and provide prognostic information.

Detailed Description

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Conditions

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Cerebral Vasospasm Cerebral Aneurysm Subarachnoid Hemorrhage

Keywords

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cerebral aneurysm subarachnoid hemorrhage cerebral vasospasm computed tomographic perfusion computed tomographic angiography

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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CTA/CTP

Patients undergo CTA/CTP imaging prior to cerebral angiography

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* subarachnoid hemorrhage after aneurysm rupture

Exclusion Criteria

* renal insufficiency
* pregnancy
* contrast reaction
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Washington University School of Medicine

OTHER

Sponsor Role lead

Responsible Party

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Michelle Miller-Thomas, MD

Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Michelle Miller-Thomas, MD

Role: PRINCIPAL_INVESTIGATOR

Washington University School of Medicine

Locations

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Barnes-Jewish Hospital

St Louis, Missouri, United States

Site Status

Countries

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United States

References

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Wintermark M, Ko NU, Smith WS, Liu S, Higashida RT, Dillon WP. Vasospasm after subarachnoid hemorrhage: utility of perfusion CT and CT angiography on diagnosis and management. AJNR Am J Neuroradiol. 2006 Jan;27(1):26-34.

Reference Type RESULT
PMID: 16418351 (View on PubMed)

Aralasmak A, Akyuz M, Ozkaynak C, Sindel T, Tuncer R. CT angiography and perfusion imaging in patients with subarachnoid hemorrhage: correlation of vasospasm to perfusion abnormality. Neuroradiology. 2009 Feb;51(2):85-93. doi: 10.1007/s00234-008-0466-7. Epub 2008 Oct 11.

Reference Type RESULT
PMID: 18850093 (View on PubMed)

Mustonen T, Koivisto T, Vanninen R, Hanninen T, Vapalahti M, Hernesniemi J, Kuikka JT, Vanninen E. Heterogeneity of cerebral perfusion 1 week after haemorrhage is an independent predictor of clinical outcome in patients with aneurysmal subarachnoid haemorrhage. J Neurol Neurosurg Psychiatry. 2008 Oct;79(10):1128-33. doi: 10.1136/jnnp.2007.142851. Epub 2008 Mar 20.

Reference Type RESULT
PMID: 18356250 (View on PubMed)

Other Identifiers

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HRPO 09-0950

Identifier Type: -

Identifier Source: org_study_id