Pocket Phantom Tool in Improving Accuracy of Quantitative PET/CT Imaging of Patients With Solid Tumors
NCT ID: NCT02822365
Last Updated: 2019-09-25
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
2 participants
OBSERVATIONAL
2016-08-24
2019-08-31
Brief Summary
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Detailed Description
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I. Optimize the pocket phantom source design and the bias estimation algorithm: determine the tolerances and variations in the source sphere geometry and radioactive filing process; evaluate the need for higher-activity sources in the presence of increased attenuation (i.e. thicker patients); optimize CT contrast levels for source boundary detection and localization from CT images; evaluate the robustness for use with different scanner parameters (e.g. CT slice thicknesses); modify bias estimation algorithm as needed to take into account changes.
II. Develop automated and robust ID pocket phantom processing and web-based software as a service (SAS) analysis tools: automate initial identification of approximate location of the pocket phantom; add automated DICOM analysis for web-based SAS analysis tools for imaging sites.
III. Conduct phantom studies at multiple imaging centers to evaluate the performance with different imaging protocols, scanners, and reconstruction methods. Also test at multiple time points over 6-9 months to assess longitudinal stability.
IV. Conduct a comparative study with patients (at University of Washington \[UW\]) at multiple time points over 6-12 months to evaluate the performance of the pocket phantom in oncology patient imaging compared with current clinical practice.
OUTLINE:
Patients undergo a PET/CT scan as part of their standard clinical care. While still positioned for the clinical scan, patients undergo additional research PET/CT scans in a smaller region over 10 minutes with the pocket phantom placed nearby and a low-dose single bed position CT scan for attenuation correction (CTAC).
Conditions
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Study Design
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CASE_ONLY
CROSS_SECTIONAL
Study Groups
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Diagnostic (PET/CT)
Patients undergo a PET/CT scan as part of their standard clinical care. While still positioned for the clinical scan, patients undergo additional research PET/CT scans in a smaller region over 10 minutes with the pocket phantom placed nearby and a low-dose single bed position CTAC.
Computed Tomography
Undergo PET/CT scan as clinically indicated (Note: CT is for attenuation correction and not for diagnostic purposes).
Imaging Phantoms
Undergo limited field of view PET scan with the Pocket Phantom placed nearby to assist in scanner calibration. No additional PET tracer will be used.
Positron Emission Tomography
Undergo PET/CT scan as clinically indicated.
Interventions
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Computed Tomography
Undergo PET/CT scan as clinically indicated (Note: CT is for attenuation correction and not for diagnostic purposes).
Imaging Phantoms
Undergo limited field of view PET scan with the Pocket Phantom placed nearby to assist in scanner calibration. No additional PET tracer will be used.
Positron Emission Tomography
Undergo PET/CT scan as clinically indicated.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Patient has a known solid tumor
* Patient provides consent
* Patient can tolerate additional time in scanner (i.e. not claustrophobic)
Exclusion Criteria
* Patient cannot or does not provide consent
21 Years
ALL
No
Sponsors
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National Cancer Institute (NCI)
NIH
University of Washington
OTHER
Responsible Party
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Principal Investigators
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Paul Kinahan
Role: PRINCIPAL_INVESTIGATOR
Fred Hutch/University of Washington Cancer Consortium
Locations
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Fred Hutch/University of Washington Cancer Consortium
Seattle, Washington, United States
Countries
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Other Identifiers
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NCI-2016-00747
Identifier Type: REGISTRY
Identifier Source: secondary_id
9592
Identifier Type: OTHER
Identifier Source: secondary_id
9592
Identifier Type: -
Identifier Source: org_study_id
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