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The Chinese Early-onset Hypertension Study (CHESS)

NCT ID: NCT02819674

Last Updated: 2018-01-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

5000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-10-31

Study Completion Date

2020-12-31

Brief Summary

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Hypertension (HTN) is the most important cardiovascular risk factor which is responsible for 50% of cardiovascular morbidity and mortality, and also a substantial public health problem affecting approximately 1/4 of the adult population in industrialized societies and over 1 billion people worldwide. Chronically elevated blood pressure without well control puts people at increased risk of target organ damages, including stroke, myocardial infarction, congestive heart failure, end-stage renal disease, blindness, and death. Especially, these damages are dramatically more severe in the early-onset hypertensive population.

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Detailed Description

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In this study, the hypertensive individuals are consecutively recruited from multiple centers, with an early onset age (less than 40 when diagnosed). A complete clinical history (information on history of hypertension, demographic characteristics, personal and family medical history) are collected by a trained staff using a standardized questionnaire on the first day of baseline observation, and physical examination are also collected in a standard procedure. Blood samples are collected after 12-hour overnight fast and biological variables are determined. Genomic DNA is isolated from leukocytes according to a standard procedure. The individuals will receive follow-up in an ordinal system. The investigators will focus on the clinical and genetic features, genotype-phenotype correlations and influencing factors of prognosis in Chinese early-onset hypertension patients.

Conditions

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Hypertension

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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early-onset hypertension

early-onset hypertension patients recruited in Chinese multiple centers

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* In accordance with the diagnosis of hypertension (BP≥140/90mmHg), and less than 40 years when diagnosed

Exclusion Criteria

\-
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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China National Center for Cardiovascular Diseases

OTHER_GOV

Sponsor Role lead

Responsible Party

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Lei.Song@NCCD

MD, ph.D

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Lei Song, MD.& PhD.

Role: PRINCIPAL_INVESTIGATOR

Chinese Academy of Medical Sciences, Fuwai Hospital

Locations

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Fuwai hospital

Beijing, Beijing Municipality, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Lei Song, MD.& PhD.

Role: CONTACT

[email protected]
86-13810532620

Lei Song, MD.& PhD.

Role: CONTACT

[email protected]
86-18600197655

Facility Contacts

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Lei Song, MD.& PhD.

Role: primary

[email protected]
86-13810532620

Lei Song, MD.& PhD.

Role: backup

[email protected]
86-18600197655

Other Identifiers

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CEHS-2016

Identifier Type: -

Identifier Source: org_study_id

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