Native Tissue Repair With Surgical Pelvic Organ Pessary - an RCT

NCT ID: NCT02808377

Last Updated: 2016-06-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

120 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-06-30

Study Completion Date

2020-06-30

Brief Summary

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This is an RCT looking at the primary outcome of composite success following anterior repair with native tissue at 6, 12, 24 months in two arms. One arm will be randomised to have a soft silicone pessary inserted into the vagina post operatively for three weeks and the other will not.

Detailed Description

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Prolapse of the vagina is a common problem for women and varies from mildly bothersome to very problematic. About one in ten women in the developed world will require surgery for prolapse in their lifetime. The results of surgery are not perfect and some of women will develop prolapse again or not be satisfied with the result.

In this study a soft silicone support (SPOP) is inserted into the vagina straight after prolapse surgery. Women who have agreed to the study will be randomly chosen to have the SPOP at the time of surgery. There will be 120 patients in the study; so 60 women will have the SPOP inserted.

The investigators think that SPOP will support the vagina as it heals, improving the results of surgery. There are already some studies of the SPOP with other surgeries that show improved results. The SPOP is inserted while the patient is sleeping and is removed four weeks after surgery. It is attached with two dissolving stiches to the vagina. After four weeks is will be removed in the out patient clinic without any discomfort. It is not usually painful or uncomfortable at any time.

The actual surgery the women have will not be any different had they not been in the study. All the women in the study will have the normal assessment prior to their operation, and will fill out some questionnaires about their symptoms too. All women involved in the study will come back the clinic to be seen after six months, one year and two years from the date of the surgery. This is regardless of whether they had the SPOP or not. When the women return they will be examined and complete the questionnaires again each visit.

The results of the study will be reported and published.

Conditions

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Pelvic Organ Prolapse

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Caregivers Investigators Outcome Assessors

Study Groups

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SPOP

This arm will have the soft silicone pessary inserted post operatively and it will remain in-situ for 3 weeks.

Group Type ACTIVE_COMPARATOR

Surgical Pelvic Organ Pessary

Intervention Type OTHER

In participants randomized to intervention, the SPOP will be placed at the completion of surgery, following routine placement of IDC and prior to placement of vaginal pack. The SPOP is available in 4 sizes and the surgeon will select the appropriate size so that the SPOP rests snugly without undue tension inside the hymeneal remnant. The SPOP is sutured in place with 2/0 Vicryl to prevent dislodgement at the level of the hymen.

Non Intervention

Routine post operative care

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Surgical Pelvic Organ Pessary

In participants randomized to intervention, the SPOP will be placed at the completion of surgery, following routine placement of IDC and prior to placement of vaginal pack. The SPOP is available in 4 sizes and the surgeon will select the appropriate size so that the SPOP rests snugly without undue tension inside the hymeneal remnant. The SPOP is sutured in place with 2/0 Vicryl to prevent dislodgement at the level of the hymen.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Women with symptomatic pelvic organ prolapse requiring an anterior vaginal repair at the study centre.
* Currently on the hospital waiting list for vaginal native tissue repair
* Willingness to participate
* Medically fit for surgery
* 18 years or over
* Reasonable level of English to complete questionnaires
* Patients have not been recommended surgery that involves colpocliesis, mesh, or laparoscopic approach

Exclusion Criteria

* Asymptomatic pelvic organ prolapse
* Refusal to participate
* Medically unfit for surgery
* Under 18
* Unable to complete questionnaires due to poor level of english
* Patients has been recommended surgery that involves colpocliesis, mesh, or laparoscopic approach
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Cambridge University Hospitals NHS Foundation Trust

OTHER

Sponsor Role lead

Responsible Party

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Dr Ivilina Pandeva

Urogynaecology Subspecialist trainee

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Department of Urogynaecology

Cambridge, Cambridgeshire, United Kingdom

Site Status

Countries

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United Kingdom

Facility Contacts

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Miss Pandeva

Role: primary

07971397396

Mark C Slack

Role: backup

Other Identifiers

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A094029

Identifier Type: -

Identifier Source: org_study_id

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