Perineal Reconstruction Following eLAPE and Simultaneous Stoma Sublay Reinforcement

NCT ID: NCT01670851

Last Updated: 2015-12-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-03-31

Study Completion Date

2015-09-30

Brief Summary

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This is a prospective, multicenter, single arm, observational pilot study to assess the clinical outcomes of Strattice Reconstructive Tissue Matrix for perineal reconstruction following eLAPE and simultaneous stoma reinforcement.

Detailed Description

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About 40 subjects will be enrolled from 4 centers over approx 24 months. Subjects will all be undergoing extralevator abdominoperineal excision with concomitant ostomy creation.

Conditions

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Rectal Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Strattice

eLAPE

Strattice

Intervention Type DEVICE

Perineal reconstruction and stoma reinforcement with Strattice

Interventions

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Strattice

Perineal reconstruction and stoma reinforcement with Strattice

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Primary cancers undergoing curative surgery (R0)
* Life expectancy \> 2 yrs
* Neoadjuvant radiotherapy with or without chemotherapy

Exclusion Criteria

* Pelvic extenteration or extended resections
* Previously irradiated patients (i.e. radiation therapy for a previous cancer)
* Co-morbidities of: systemic infection, chronic liver failure, chronic renal failure, HIV, Hepatitis C, other advanced/metastatic cancer, collagen disorder
* sensitivity to porcine derived products or polysorbate
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Karolinska University Hospital

OTHER

Sponsor Role collaborator

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

OTHER

Sponsor Role collaborator

Slagelse Hospital

OTHER

Sponsor Role collaborator

University Hospitals, Leicester

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Baljit Singh, FRCS, FACS

Role: PRINCIPAL_INVESTIGATOR

University Hospital Leicester, UK

Sanjay Chaudhri, FRCS

Role: PRINCIPAL_INVESTIGATOR

University Hospital Leicester, UK

Per J Nilsson, MD

Role: PRINCIPAL_INVESTIGATOR

Karolinska Institutet

Pierre J Maina, MD

Role: PRINCIPAL_INVESTIGATOR

Slagelse Hospital, Denmark

W Bemelman, MD

Role: PRINCIPAL_INVESTIGATOR

Academic Medical Center, Amsterdam, Netherlands

Locations

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Slagelse Hospital

Slagelse, , Denmark

Site Status

Karolinska University Hospital

Stockholm, , Sweden

Site Status

University Hospitals Leicester

Leicester, , United Kingdom

Site Status

Countries

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Denmark Sweden United Kingdom

Other Identifiers

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ISIS.11.01.06.BS/SC

Identifier Type: -

Identifier Source: org_study_id