Vascular Aging in Flight Attendants With Occupational Secondhand Smoke Exposure
NCT ID: NCT02795624
Last Updated: 2021-08-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
300 participants
OBSERVATIONAL
2016-02-29
2021-08-31
Brief Summary
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It is hypothesized that pre-ban FA cases have increased arterial stiffness (higher pulse wave velocity and higher augmentation index) and increased endothelial dysfunction (lower reactive hyperemia index) compared to Framingham controls.
Specific Aim 2. Determine the extent in which remote pre-ban SHS exposure (hours) is associated with increased arterial stiffness or endothelial dysfunction.
Investigators hypothesize that pre-ban SHS exposure is positively associated with both increased arterial stiffness and increased endothelial dysfunction.
Specific Aim 3. Investigators will calculate the cardiovascular risk scores (Framingham, Reynolds, and ASCVD) by using subjects' age, blood pressure, family history, lipid panel, and highly sensitive C-reactive protein. Investigators will explore the association of the risk scores with measures of vascular aging (arterial stiffness and endothelial dysfunction). These scores do not include SHS exposure. Investigators will also test the additive value of SHS exposure in increasing arterial stiffness and endothelial dysfunction using the risk scores as an adjustment value.
It is hypothesized that the cardiovascular risk scores are associated with vascular aging (arterial stiffness and endothelial dysfunction), and that the association between SHS exposure and vascular aging remains significant after adjusting for the cardiovascular risk scores.
The significance of this proposal and impact will be (1) mechanistic insights into how remote SHS exposure leads to hypertension and vascular stiffness, (2) increased understanding of how SHS exposure can increase risk of cardiovascular disease, which is the number one cause of death in the United States.
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Flight attendants
Flight attendants
Spirometry
Test is done to assess how well the lungs work by measuring how much air is inhaled, how much is exhaled, and how quickly it is exhaled.
Pulse Wave Analysis
It is a non-invasive assessment of the pulse character
Peripheral arterial tonometry
It is a non-invasive method to measure endothelial dysfunction.
Interventions
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Spirometry
Test is done to assess how well the lungs work by measuring how much air is inhaled, how much is exhaled, and how quickly it is exhaled.
Pulse Wave Analysis
It is a non-invasive assessment of the pulse character
Peripheral arterial tonometry
It is a non-invasive method to measure endothelial dysfunction.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Flight attendant, including current or past employment with the airlines;
* Non-smoking flight attendant (current and prior, defined as smoking \<100 cigarettes in your lifetime);
* Exposed to secondhand tobacco smoke for at least one year, while working on the aircrafts
Exclusion Criteria
* Had mastectomy or arm/hand abnormality in which blood pressure cannot be measured on the arm
40 Years
ALL
No
Sponsors
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University of California, San Francisco
OTHER
Cedars-Sinai Medical Center
OTHER
Responsible Party
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Noel Bairey Merz
Director
Principal Investigators
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C.Noel Bairey Merz, MD, FACC
Role: PRINCIPAL_INVESTIGATOR
Cedars-Sinai Medical Center
Locations
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Cedars-Sinai Women's Heart Center
Los Angeles, California, United States
Countries
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Other Identifiers
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Pro00042101
Identifier Type: -
Identifier Source: org_study_id
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