Effect of Resistance Training on Tobacco-Related Cardiovascular Disease Risk
NCT ID: NCT01705951
Last Updated: 2012-10-12
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
100 participants
INTERVENTIONAL
2011-04-30
2013-12-31
Brief Summary
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The investigators hypothesize that resistance training will improve cardiovascular function in smokers; however, the responses will be better in those who also stop smoking. In addition, resistance training will decrease smoking, however, the effects of counseling and nicotine replacement alone or counseling and nicotine replacement in conjunction with resistance training will be better than resistance training alone.
Detailed Description
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At week 0, participants attend three outpatient visits at baseline. Each participant is randomized to one of four groups: Resistance Training(RT)/Nicotine Replacement Therapy (NRT), RT/No NRT, No RT/NRT, and No RT/No NRT. Those receiving RT work with a certified personal trainer 3 times per week for 12 weeks at 60 minutes each session. Those receiving NRT use the nicotine patch daily for 12 weeks and call the California Smoker's Helpline for smoking cessation counseling. Those in the control group do not receive any intervention and maintain their current lifestyle and habits.
At week 13, participants return for three post-intervention assessments.
At week 26, survey data is collected to assess changes in lifestyle habits.
Conditions
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Keywords
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Study Design
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RANDOMIZED
FACTORIAL
TREATMENT
NONE
Study Groups
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Group 1: Resistance Training/Nicotine Replacement
Resistance Training (RT)
Resistance Training program 3x/week at 60 minutes per session for 12 weeks.
Nicotine Replacement Therapy (NRT)
Nicotine patch for 12 weeks (21mg, 14mg, 7mg.) and referral to California Smoker's Helpline for 6 sessions of smoking cessation counseling.
Group 2: Resistance Training only
Resistance Training (RT)
Resistance Training program 3x/week at 60 minutes per session for 12 weeks.
Group 3: Nicotine Replacement Therapy only
Nicotine Replacement Therapy (NRT)
Nicotine patch for 12 weeks (21mg, 14mg, 7mg.) and referral to California Smoker's Helpline for 6 sessions of smoking cessation counseling.
Group 4: Control; no RT and no NRT
No interventions assigned to this group
Interventions
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Resistance Training (RT)
Resistance Training program 3x/week at 60 minutes per session for 12 weeks.
Nicotine Replacement Therapy (NRT)
Nicotine patch for 12 weeks (21mg, 14mg, 7mg.) and referral to California Smoker's Helpline for 6 sessions of smoking cessation counseling.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Male and female smokers
* Smokers (smoked at least one cigarette a day for 15 or more days in the last month and has smoked 100 cigarettes in life)
* 1-3 years experience consistently exercising/training at ≤2 days/wk of RT and ≤1 day/wk of aerobic exercise
* Capable of providing informed consent
* UCLA students/staff and Non UCLA student/staff
* Participant in good health as determined by baseline visit
Exclusion Criteria
* Has had cardiac surgery
* Currently in weight loss or exercise program in the 6 months prior to participation.
* Use of medications that influence CV function or preclude the ability to train
* Syndromes or prescribed medications that may influence CVD, body composition, or insulin action (e.g. prednisone, Ritalin, Adderall, GH)
* Unable to exercise
* Diagnosed with syndromes or diseases that may influence body composition and CV risk (e.g. Cushing syndrome).
* Known heart arrhythmia and/or abnormalities found in electrocardiogram (ECG) reading that would prevent someone from performing the exercise intervention. If the subject demonstrates abnormal ECG during their pre-intervention visit (or any follow-up visit) the subject's ECG will be reviewed (for approval) by a cardiologist to continue in the study.
* Pregnant
* Use of hormonal contraceptives
* Currently in a smoking cessation program including use of NRT within the month of participation
18 Years
35 Years
ALL
Yes
Sponsors
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University of California
OTHER
University of California, Los Angeles
OTHER
Responsible Party
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Christian Roberts, PhD
Research Associate Professor
Principal Investigators
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Christian K Roberts, Ph.D
Role: PRINCIPAL_INVESTIGATOR
University of California, Los Angeles
Locations
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University of California, Los Angeles
Los Angeles, California, United States
Countries
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Central Contacts
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Other Identifiers
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19KT-0028
Identifier Type: -
Identifier Source: org_study_id