Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
9 participants
INTERVENTIONAL
2016-05-30
2017-01-15
Brief Summary
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In order to investigate the fat metabolizing effects of GH, we'll analyze consecutive adipose tissue biopsies taken after GH exposure and GH blocking, respectively.
Knowledge of the effects of growth hormone and fat metabolism can in shot-sight as well as in long-sight have great importance for the understanding of growth disorders from overweight and type 2 diabetes to malnutrition and eating disorders.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
SINGLE
Study Groups
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Growth hormone
Subjects are receiving growth hormone
Growth Hormone
Subjects are receiving one injection of growth hormone (Genotropin) 0,5 mg
Placebo
Subjects are receiving pegvisomant to block the action of growth hormone
Pegisomant
One the placebo day the subjects are receiving injection with pegvisomant (Somavert 30 mg) to block the action of endogenous growth hormone
Interventions
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Growth Hormone
Subjects are receiving one injection of growth hormone (Genotropin) 0,5 mg
Pegisomant
One the placebo day the subjects are receiving injection with pegvisomant (Somavert 30 mg) to block the action of endogenous growth hormone
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* no medication
* BMI 28-35
Exclusion Criteria
* regular medication
18 Years
60 Years
MALE
Yes
Sponsors
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University of Aarhus
OTHER
Responsible Party
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Principal Investigators
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Jens Otto L Jørgensen, Professor
Role: PRINCIPAL_INVESTIGATOR
University Hospital of Aarhus
Locations
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University Hospital of Aarhus
Aarhus, , Denmark
Countries
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References
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Nielsen TS, Jessen N, Jorgensen JO, Moller N, Lund S. Dissecting adipose tissue lipolysis: molecular regulation and implications for metabolic disease. J Mol Endocrinol. 2014 Jun;52(3):R199-222. doi: 10.1530/JME-13-0277. Epub 2014 Feb 27.
Moller N, Jorgensen JO. Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects. Endocr Rev. 2009 Apr;30(2):152-77. doi: 10.1210/er.2008-0027. Epub 2009 Feb 24.
Hjelholt AJ, Lee KY, Arlien-Soborg MC, Pedersen SB, Kopchick JJ, Puri V, Jessen N, Jorgensen JOL. Temporal patterns of lipolytic regulators in adipose tissue after acute growth hormone exposure in human subjects: A randomized controlled crossover trial. Mol Metab. 2019 Nov;29:65-75. doi: 10.1016/j.molmet.2019.08.013. Epub 2019 Aug 20.
Other Identifiers
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GH02
Identifier Type: -
Identifier Source: org_study_id
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