Influence of Gender Specific Differences of Saliva Composition on the Development of Dental Erosion - an In-situ Study
NCT ID: NCT02780973
Last Updated: 2024-02-14
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
50 participants
OBSERVATIONAL
2017-02-07
2018-01-18
Brief Summary
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Total protein concentration within the formed salivary pellicles on the bovine samples is determined. Further Salivary parameters (unstimulated and stimulated saliva flow rate, pH, buffer capacity, albumin and total protein content as well as concentration of inorganic calcium, phosphate and fluoride) are being measured.
The aim of this study is to investigate whether gender differences in the salivary composition correlate with predisposition to erosion.
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Females
Female volunteers
Wearing of an intraoral device with bovine tooth samples
Wearing of an intraoral device with bovine tooth samples
Males
Male volunteers
Wearing of an intraoral device with bovine tooth samples
Wearing of an intraoral device with bovine tooth samples
Interventions
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Wearing of an intraoral device with bovine tooth samples
Wearing of an intraoral device with bovine tooth samples
Eligibility Criteria
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Inclusion Criteria
* Smoking
* Hyposalivation / xerostomia (unstimulated saliva \< 0.3 mL/min, stimulated saliva \< 0.7 mL/min)
* Intake of any medication (except contraceptives in women)
* Pregnant or lactating women
* Known allergies to substances used in the study
* Orthodontic treatment or malfunction which doesn't allow to wear an intraoral device
20 Years
40 Years
ALL
Yes
Sponsors
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University of Göttingen
OTHER
Responsible Party
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Philipp Kanzow, PD Dr. med. dent., Dr. rer. medic.
Senior Dental Practitioner
Principal Investigators
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Annette Wiegand, Prof. Dr. med. dent.
Role: PRINCIPAL_INVESTIGATOR
Dept. of Prev. Dentistry, Periodontology and Cariology, University Medical Center Göttingen, Germany
Locations
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University Medical Center Göttingen, Dept. of Preventive Dentistry, Periodontology and Cariology
Göttingen, Lower Saxony, Germany
Countries
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References
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Prodan A, Brand HS, Ligtenberg AJ, Imangaliyev S, Tsivtsivadze E, van der Weijden F, Crielaard W, Keijser BJ, Veerman EC. Interindividual variation, correlations, and sex-related differences in the salivary biochemistry of young healthy adults. Eur J Oral Sci. 2015 Jun;123(3):149-57. doi: 10.1111/eos.12182. Epub 2015 Mar 23.
Carpenter G, Cotroneo E, Moazzez R, Rojas-Serrano M, Donaldson N, Austin R, Zaidel L, Bartlett D, Proctor G. Composition of enamel pellicle from dental erosion patients. Caries Res. 2014;48(5):361-7. doi: 10.1159/000356973. Epub 2014 Mar 6.
Moazzez R, Bartlett D. Intrinsic causes of erosion. Monogr Oral Sci. 2014;25:180-96. doi: 10.1159/000360369. Epub 2014 Jun 26.
Wiegand A, Bliggenstorfer S, Magalhaes AC, Sener B, Attin T. Impact of the in situ formed salivary pellicle on enamel and dentine erosion induced by different acids. Acta Odontol Scand. 2008 Aug;66(4):225-30. doi: 10.1080/00016350802183401.
Wiegand A, Meier W, Sutter E, Magalhaes AC, Becker K, Roos M, Attin T. Protective effect of different tetrafluorides on erosion of pellicle-free and pellicle-covered enamel and dentine. Caries Res. 2008;42(4):247-54. doi: 10.1159/000135669. Epub 2008 Jun 4.
Zwier N, Huysmans MC, Jager DH, Ruben J, Bronkhorst EM, Truin GJ. Saliva parameters and erosive wear in adolescents. Caries Res. 2013;47(6):548-52. doi: 10.1159/000350361. Epub 2013 Jun 15.
Kanzow P, Wegehaupt FJ, Attin T, Wiegand A. Etiology and pathogenesis of dental erosion. Quintessence Int. 2016 Apr;47(4):275-8. doi: 10.3290/j.qi.a35625.
Wiegand A, Rosemann A, Hoch M, Barke S, Dakna M, Kanzow P. Erosion-Protective Capacity of the Salivary Pellicle of Female and Male Subjects Is Not Different. Caries Res. 2019;53(6):636-642. doi: 10.1159/000500046. Epub 2019 Jun 4.
Other Identifiers
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7/10/15
Identifier Type: OTHER
Identifier Source: secondary_id
01681
Identifier Type: OTHER
Identifier Source: secondary_id
Erosion-Gender
Identifier Type: -
Identifier Source: org_study_id
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