ConfidenHT System for Diagnostic Electrical Mapping of Renal Nerves

NCT ID: NCT02777216

Last Updated: 2018-02-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-10-31

Study Completion Date

2017-12-31

Brief Summary

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To evaluate the safety and performance of the ConfidenHT System

Detailed Description

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To evaluate the safety and performance of the ConfidenHT System for diagnostic mapping of renal nerves; functional distribution of renal nerves and the effect of renal nerve stimulation on the blood pressure

Conditions

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Hypertension

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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ConfidenHT system

ConfidenHT system

Group Type EXPERIMENTAL

ConfidenHT system

Intervention Type DEVICE

ConfidenHT Medical system

Interventions

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ConfidenHT system

ConfidenHT Medical system

Intervention Type DEVICE

Other Intervention Names

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ConfidenHT Medical system

Eligibility Criteria

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Inclusion Criteria

1. Signed written informed consent.
2. Age \>18 years and \<75.
3. Either:

1. Hypertensive patients planned to undergo elective cardiac catheterization
2. Potential candidates for renal sympathetic denervation
4. Main renal artery with diameter ≥ 4.0mm.
5. Glomerular Filtration Rate (GFR) \>45 mL/min
6. A patient who is mentally competent with the ability to understand and comply with the requirements of the study.
7. The patient agrees to attend all follow-up evaluations and is willing to complete required exams and tests.
8. Female patients with childbearing potential must agree:

* to use a valid method of contraception (oral contraceptives, intrauterine device, subcutaneous contraceptive implant, vaginal ring)
* to perform a pregnancy test

Exclusion Criteria

1. Previous participation in another study with any investigational drug or device within the past 30 days.
2. Relevant renal artery disease (% diameter stenosis\>30%, aneurysm or fibromuscular dysplasia).
3. Known secondary causes of hypertension.
4. The patient has a life expectancy ≤ 12 months.
5. The patient has undergone prior renal denervation, renal stenting, and/or abdominal aortic stent grafts.
6. The patient has chronic oxygen use other than nocturnal support for sleep apnea.
7. The patient has type I diabetes mellitus.
8. The patient has had a previous organ transplant or is awaiting a renal transplant.
9. Active implantable medical device (e.g. ICD or CRT-D; neuromodulator/spinal stimulator; baroreflex stimulator).
10. The patient has triple ipsilateral artery ostia.
11. Moderate to severe valvular heart disease.
12. The patient has other concomitant conditions that may adversely affect the patient or the study outcome.
13. Female who is pregnant, nursing or planning to become pregnant.
14. Documented contraindication or allergy to contrast medium not amenable to treatment.
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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BlueWind Medical

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Kostas Tsioufis, MD

Role: PRINCIPAL_INVESTIGATOR

Hippocratio Hospital, Athens, Greece

Locations

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Hippocratio Hospital

Athens, , Greece

Site Status

EMC

Rotterdam, , Netherlands

Site Status

UMC

Utrecht, , Netherlands

Site Status

Countries

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Greece Netherlands

Other Identifiers

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167CLP

Identifier Type: -

Identifier Source: org_study_id

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