Insulin Sensitivity and Secretion During Pregnancy and Post Partum in Women With Gestational Diabetes.
NCT ID: NCT02770079
Last Updated: 2019-09-27
Study Results
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Basic Information
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COMPLETED
10 participants
OBSERVATIONAL
2016-05-31
2019-09-30
Brief Summary
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To define insulin requirement during pregnancy and to identify the rapid changes in insulin sensitivity around parturition and the first 6 months post partum. Such knowledge would be clinically useful and markedly improve insulin treatment before and after parturition for women with type 1 diabetes and serve to identify the best possible timing of testing women with gestational diabetes mellitus (GDM) for the development of type 2 diabetes post partum.
Method:
Botnia clamp in women before, immediately after delivery and 6 months post partum. The investigators will compare 20 women with GDM in late pregnancy, day 15 post partum and 6 months post partum with 20 normal women investigated at the same time points. In addition the investigators will collect feces samples from the mother and baby in order to determine microbiota.
Perspectives:
Diabetes is a common condition with important implications for pregnancy outcome and long-term morbidity for mother and offspring. Accordingly, tailoring the best treatment is expected to have beneficial consequences both for the pregnant women and the future generation.
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Gestational diabetes
10 women with gestational diabetes
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Pregnant.
* GDM for the GDM group.
* No diabetes for the control group.
Exclusion Criteria
* New pregnancy before all three examinations has been done.
* Severe, debilitating, concurrent diseases.
* Serious or intolerable adverse reactions associated with the studies.
18 Years
50 Years
FEMALE
Yes
Sponsors
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University of Aarhus
OTHER
Responsible Party
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Principal Investigators
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Per G Ovesen, MD, DMSc
Role: PRINCIPAL_INVESTIGATOR
University of Aarhus
Locations
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Aarhus University Hospital, NBG
Aarhus, , Denmark
Countries
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References
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Skajaa GO, Fuglsang J, Knorr S, Moller N, Ovesen P, Kampmann U. Changes in insulin sensitivity and insulin secretion during pregnancy and post partum in women with gestational diabetes. BMJ Open Diabetes Res Care. 2020 Oct;8(2):e001728. doi: 10.1136/bmjdrc-2020-001728.
Other Identifiers
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GDM_Clamp_Skajaa
Identifier Type: -
Identifier Source: org_study_id
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