Oxytocin Effects on Likeability After Being Liked or Disliked

NCT ID: NCT02745431

Last Updated: 2017-08-01

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 86 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2015-06-30
• Study Completion Date: 2016-06-30

Brief Summary

The current study aimed to investigate oxytocin effect on the response after the experience of being liked or disliked.

Detailed Description

In a double-blind, between-subject, placebo controlled design study, the researchers aimed to investigate the intranasal OXT (40IU) treatment on rating response after being liked or disliked in healthy male subjects. All subjects completed a range of questionnaires measuring personality and affective traits and levels of anxiety: Positive and Negative Affect Schedule (PANAS) , State-Trait Anxiety Inventory (STAI) , Beck Depression Inventory (BDI), Cheek and Buss shyness Scale (CBSS),Autism Spectrum Quotient (ASQ), Empathy Quotient(EQ) before self-administration.Study participants were led to believe that other participants had formed an opinion on their likability based on their appearance in a photograph and they passively viewed the responses (like or dislike) from 'other participants'. After that, they rated 'other participants' about likeability (how much do you like the person), accuracy (have you seen the person), feeling (how good do you feel), and tendency (how much would do like have him/her as a friend). Likeability, tendency, feeling and accuracy were included into analysis as dependent variables.

Conditions

Social Behavior

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: DOUBLE

Study Groups

Oxytocin nasal spray

Oxytocin nasal spray

Group Type: EXPERIMENTAL

Oxytocin

Intervention Type: DRUG

Placebo nasal spray

Placebo nasal spray

Group Type: PLACEBO_COMPARATOR

Placebo

Intervention Type: DRUG

Interventions

Oxytocin

Intervention Type: DRUG

Placebo

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Healthy subjects without past or current psychiatric or neurological disorder

Exclusion Criteria

• history of head injury;
• claustrophobia;
• medical or psychiatric illness.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 30 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

University of Electronic Science and Technology of China

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

School of Life Science and Technology, University of Electronic Science and Technology

Chengdu, Sichuan, China

Countries

China

References

Zhao W, Ma X, Le J, Ling A, Xin F, Kou J, Zhang Y, Luo R, Becker B, Kendrick KM. Oxytocin biases men to be more or less tolerant of others' dislike dependent upon their relationship status. Psychoneuroendocrinology. 2018 Feb;88:167-172. doi: 10.1016/j.psyneuen.2017.12.010. Epub 2017 Dec 22.

Reference Type: DERIVED

PMID: 29304421 (View on PubMed)

Other Identifiers

UESTC-neuSCAN-06

Identifier Type: -

Identifier Source: org_study_id