Brain Derived Neurotropic Factor Response to Aerobic Exercise Intensity in Depressive Patients.

NCT ID: NCT02741622

Last Updated: 2018-12-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

21 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-03-31

Study Completion Date

2016-12-31

Brief Summary

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Acute aerobic exercise improves affective stats in patients with mental illnesses. Brain derived neurotropic factor (BDNF) may be a biological mechanism that contributes to the affective benefits. The magnitude of the increase of serum BDNF might be exercise intensity dependent, but no study has compared low high-aerobic-intensity training at 90-95 % of the maximal heart rate (HRmax) with long-slow-distance training at 70 % of the HRmax in patients with depression.

The aim of this study is to compare changes in serum BDNF levels after high-aerobic-intensity training and long-slow-distance training in a intra-individual design in patients suffering from depression. The results will give indications of a possible difference in BDNF response between aerobic intensities and may be uses as pilot data for calculating sample size.

Detailed Description

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Conditions

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Depressive Disorder Depressive Disorder, Major

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Exercise

Acute High aerobic intensity training (HIT) and long slow distance training (LSD)

Group Type EXPERIMENTAL

High aerobic intensity training (HIT)

Intervention Type BEHAVIORAL

One training session, high aerobic intensity training (HIT) at 90-95 % of the maximal heart rate (HRmax)

Long slow distance training (LSD)

Intervention Type BEHAVIORAL

One training session, long slow distance training (LSD) at 70 % of the HRmax

Interventions

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High aerobic intensity training (HIT)

One training session, high aerobic intensity training (HIT) at 90-95 % of the maximal heart rate (HRmax)

Intervention Type BEHAVIORAL

Long slow distance training (LSD)

One training session, long slow distance training (LSD) at 70 % of the HRmax

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Moderate or severe depression (ICD10: F32-F33)

Exclusion Criteria

* Bipolar disorder.
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Norwegian University of Science and Technology

OTHER

Sponsor Role collaborator

St. Olavs Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Pål Sandvik, MD

Role: STUDY_DIRECTOR

St.Olavs University Hospital, Østmarka

Locations

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St.Olavs university Hospital, Departement of Østmarka

Trondheim, , Norway

Site Status

Countries

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Norway

Other Identifiers

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2015/2230

Identifier Type: -

Identifier Source: org_study_id

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