Effectiveness of Walking Exercise in Improving Depression in Older Adults With Major Depressive Disorder, A Pilot Study

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

35 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-11-01

Study Completion Date

2020-12-31

Brief Summary

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1. This pilot randomized controlled trial aims at investigating the effects of different intensities of aerobic walking exercise to alleviate depression in older adults with major depressive disorder. Both baseline and post-intervention measurements will be conducted at the Exercise Physiology Laboratory, Division of Kinesiology, School of Public Health, The University of Hong Kong, while the exercise intervention will be conducted outdoors in a small group setting (3-5 participants).
2. Three-time-per-week moderate-intensity (\~3.5 METs) or vigorous-intensity (\~7 METs) walking exercise will be prescribed to participants in two exercise groups, while the participants in the waitlist group will receive no intervention. The intervention duration is 12 weeks.
3. We will recruit participants from the community in HK. Interested participants will be invited for a semi-structured interview including an assessment on the Beck Depression Inventory and medical history record to confirm eligibility.

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Detailed Description

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Conditions

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Major Depressive Disorder (MDD)

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Outcomes assessor will be blinded from the group allocation and the participants are instructed not to reveal what kind of intervention he/she received.

Study Groups

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Waitlist control group

Participants in this group receive no intervention during the 12-week period.

Group Type PLACEBO_COMPARATOR

Waitlist control

Intervention Type BEHAVIORAL

waitlist control

Moderate-intensity walking group

Participants in this group will perform a thrice-a-week walking exercise at a moderate intensity (\~3.5 METs). The training will be conducted outdoors. Each training session lasts for 50 minutes.

Group Type EXPERIMENTAL

Moderate-intensity walking exercise

Intervention Type BEHAVIORAL

walking exercise

Vigorous-intensity walking group

Participants in this group will perform a thrice-a-week walking exercise at a vigorous intensity (\~7 METs). The training will be conducted outdoors. Each training session lasts for 25 minutes.

Group Type EXPERIMENTAL

Vigorous-intensity walking exercise

Intervention Type BEHAVIORAL

walking exercise

Interventions

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Waitlist control

waitlist control

Intervention Type BEHAVIORAL

Moderate-intensity walking exercise

walking exercise

Intervention Type BEHAVIORAL

Vigorous-intensity walking exercise

walking exercise

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

1. Older adults aged equal or over 50 years;
2. Ethnic Chinese;
3. Beck Depression Inventory score over 9 points;
4. Diagnosed with MDD and currently on pharmacological treatment for MDD.

Exclusion Criteria

1. Incapable of participating in physical exercise with major confounding conditions which are known to affect mobility;
2. Cannot walk without assistive device;
3. Regular exercise habit (defined as exercise \> 3 times per week and each time \> 50 minutes)
4. Any serious somatic condition that prevents walking exercise participation (such as limb loss)
5. History of major diseases e.g. cancer, cardio-/cerebrovascular, neurodegenerative and renal diseases;
6. Diagnosis of dementia/Alzheimer's disease, or currently using antidementia medication;

Minimum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No