Sparsity-based Magnetic Resonance Imaging of Cardiac Arrhythmias

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

SUSPENDED

Clinical Phase

NA

Total Enrollment

135 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-09-29

Study Completion Date

2026-08-31

Brief Summary

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The primary purpose of this study is to improve the quality of Magnetic Resonance Imaging in patients with heart arrhythmia. Investigators will recruit 105 patients with arrhythmia and 30 control volunteers over 3 years and will use two arrhythmia-tolerant imaging methods for diagnosis.

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RECRUITING

Detailed Description

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In the proposed research, investigators will extend conventional cardiac magnetic resonance methods to enable the creation of high-quality cine CMR images in the presence of multiple kinds of arrhythmia. Two arrhythmia-tolerant imaging methods will be adopted, which are particularly useful in arrhythmia: 1) 3D imaging, which is useful for many purposes, including "road mapping" of electrophysiology (EP) procedures, and 2) late gadolinium enhancement (LGE), which is useful for delineating abnormal myocardium, including fibrotic regions that can serve as sources of arrhythmias.

Conditions

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Cardiac Arrythmias

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Patients with Arrhythmias

Group Type OTHER

3D Imaging

Intervention Type OTHER

"roadmapping" of electrophysiology (EP) procedures

Late Gadolinium Enhancement (LGE)

Intervention Type OTHER

useful for delineating abnormal myocardium, including fibrotic regions that can serve as sources of arrhythmias.

Healthy Control

Group Type OTHER

3D Imaging

Intervention Type OTHER

"roadmapping" of electrophysiology (EP) procedures

Late Gadolinium Enhancement (LGE)

Intervention Type OTHER

useful for delineating abnormal myocardium, including fibrotic regions that can serve as sources of arrhythmias.

Interventions

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3D Imaging

"roadmapping" of electrophysiology (EP) procedures

Intervention Type OTHER

Late Gadolinium Enhancement (LGE)

useful for delineating abnormal myocardium, including fibrotic regions that can serve as sources of arrhythmias.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients diagnosed with heart arrhythmia scheduled for routine clinical MRI examinations).
* Patients scheduled for routine clinical MRI examinations who do not have a specific known diagnosis of arrhythmia, but who may be found to have image degradation due to arrhythmia during the CMR examination.

* No history of heart arrhythmia.

Exclusion Criteria

* Hemodynamic instability.
* Contraindications for MRI examinations (e.g., pacemakers or ferromagnetic vascular clips).
* History of prior cardiovascular disease or significant risk factors:

* Diabetes, hypertension, smoking, and hyperlipidemia, etc.

Minimum Eligible Age

10 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes