Evaluation of N1539 Following Major Surgery

NCT ID: NCT02720692

Last Updated: 2023-06-22

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE3
• Total Enrollment: 722 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2016-03-31
• Study Completion Date: 2017-05-31

Brief Summary

The primary objective of this study is to evaluate the safety and tolerability of N1539 in a variety of post-surgical conditions.

Conditions

Pain, Post-operative

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: QUADRUPLE

Study Groups

N1539 30mg

N1539 (Intravenous meloxicam) 30mg every 24 hours for up to 7 doses.

Group Type: EXPERIMENTAL

N1539

Intervention Type: DRUG

IV Placebo

IV Placebo every 24 hours for up to 7 doses.

Group Type: PLACEBO_COMPARATOR

Intravenous Placebo

Intervention Type: DRUG

Interventions

N1539

Intervention Type: DRUG

Intravenous Placebo

Intervention Type: DRUG

Other Intervention Names

Intravenous meloxicam

Eligibility Criteria

Inclusion Criteria

• Voluntarily provide written informed consent.
• Male or female between 18 and 80 years of age, inclusive.
• Be planning to undergo major elective surgery, and be expected to require intravenous analgesia and remain in an inpatient setting for at least 24-48 hours and are expected to receive at least two study doses.
• Female subjects are eligible only if all the following apply:

• Not pregnant;
• Not breastfeeding;
• Not able to become pregnant;
• Not planning to become pregnant during the study or 28 day follow up;
• Commit to the use of an acceptable form of birth control for the duration of the study.
• Have a body mass index ≤40 kg/m2
• Be able to understand the study procedures, comply with all study procedures, and agree to participate in the study program.
• For oncology cases, have a histologically confirmed diagnosis of a primary solid tumor, affecting any one of the following organs: breast, skin, colon, prostate, uterus, ovaries, urethra, penis, or vulva; AND based on clinical, laboratory, radiologic, pathologic, and surgical findings, the tumor is confined to the primary organ, without evidence of local, regional or distal spread; AND have a performance status such that they are able to carry on normal activities of daily life without limitations.

Exclusion Criteria

• Have a known allergy to meloxicam or any excipient of N1539, aspirin, other non-steroidal anti-inflammatory drugs (NSAIDs).
• Be scheduled to undergo cranial surgery, open heart procedure, any type of coronary artery bypass graft, organ transplant, or any other surgical procedure in which NSAIDs are contraindicated.
• Planned or actual admission to the intensive care unit at any time during study participation.
• Have clinically significant laboratory abnormalities.
• Have a history of myocardial infarction within the preceding 12 months.
• Have history of HIV, or hepatitis B or C.
• Have a history or clinical manifestations of significant renal, hepatic, cardiovascular, metabolic, neurologic, psychiatric, respiratory, or other condition that would preclude participation in the study.
• Have active or recent (within 6 months) gastrointestinal ulceration or bleeding
• Have a known bleeding disorder which may be worsened with the administration of a NSAID.
• Have evidence of a clinically significant 12 lead ECG abnormality.
• Have a history of alcohol abuse (regularly drinks > 4 units of alcohol per day; 8 oz. beer, 3 oz. wine, 1 oz. spirits) or a history of prescription/illicit drug abuse within the past 5 years.
• Have positive results on the urine drug screen for cocaine or PCP or alcohol breath test indicative of illicit drug or alcohol abuse.
• Unable to discontinue medications, that have not been at a stable dose for at least 14 days prior to the scheduled surgical procedure, within 5 half-lives of the specific prior medication (or, if half-life is not known, within 48 hours) before dosing with study medication.
• Be unable to discontinue herbal medications at least 7 days prior to surgery through last dose of study medication.
• Be receiving lithium, or a combination of furosemide with either an angiotensin converting enzyme inhibitor or an angiotensin receptor blocker
• Be currently receiving treatment with oral meloxicam (Mobic®) or other NSAID within 7 days prior to surgery.
• Have received any investigational product within 30 days before dosing with study medication.
• Have previously received N1539 in clinical trials, or had major surgery in the last 3 months that would interfere with study assessments.
• Have undergone or be expected to undergo radiation therapy, chemotherapy, or other biological therapy for cancer treatment, within 60 days prior to screening, through the last study visit, approximately 30 days after dosing.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Baudax Bio

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Florence, Alabama, United States

Montgomery, Alabama, United States

Sheffield, Alabama, United States

Gilbert, Arizona, United States

Phoenix, Arizona, United States

Anaheim, California, United States

Bakersfield, California, United States

Miami, Florida, United States

Tamarac, Florida, United States

Tampa, Florida, United States

Chicago, Illinois, United States

Great Falls, Montana, United States

Cleveland, Ohio, United States

Columbus, Ohio, United States

Tyrone, Pennsylvania, United States

Hendersonville, Tennessee, United States

Houston, Texas, United States

Houston, Texas, United States

San Antonio, Texas, United States

Salt Lake City, Utah, United States

Chermside, Queensland, Australia

Kippa-Ring, Queensland, Australia

Southport, Queensland, Australia

Richmond, Victoria, Australia

Halifax, Nova Scotia, Canada

Kingston, Ontario, Canada

Toronto, Ontario, Canada

Montreal, Quebec, Canada

Montreal, Quebec, Canada

Auckland, , New Zealand

Christchurch, , New Zealand

Hamilton, , New Zealand

Countries

United States; Australia; Canada; New Zealand

References

Sharpe KP, Berkowitz R, Tyndall WA, Boyer D, McCallum SW, Mack RJ, Du W. Safety, Tolerability, and Effect on Opioid Use of Meloxicam IV Following Orthopedic Surgery. J Pain Res. 2020 Jan 21;13:221-229. doi: 10.2147/JPR.S216219. eCollection 2020.

Reference Type: DERIVED

PMID: 32021411 (View on PubMed)

Bergese SD, Melson TI, Candiotti KA, Ayad SS, Mack RJ, McCallum SW, Du W, Gomez A, Marcet JE. A Phase 3, Randomized, Placebo-Controlled Evaluation of the Safety of Intravenous Meloxicam Following Major Surgery. Clin Pharmacol Drug Dev. 2019 Nov;8(8):1062-1072. doi: 10.1002/cpdd.666. Epub 2019 Feb 20.

Reference Type: DERIVED

PMID: 30786162 (View on PubMed)

Viscusi ER, Gan TJ, Bergese S, Singla N, Mack RJ, McCallum SW, Du W, Hobson S. Intravenous meloxicam for the treatment of moderate to severe acute pain: a pooled analysis of safety and opioid-reducing effects. Reg Anesth Pain Med. 2019 Mar;44(3):360-368. doi: 10.1136/rapm-2018-100184. Epub 2019 Feb 7.

Reference Type: DERIVED

PMID: 30737315 (View on PubMed)

Provided Documents

Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

REC-15-017

Identifier Type: -

Identifier Source: org_study_id