Use of Hyaluronic Acid as a Therapeutic Strategy for Bone Repair in Human

NCT ID: NCT02709525

Last Updated: 2016-03-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1/PHASE2

Total Enrollment

16 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-07-31

Study Completion Date

2016-03-31

Brief Summary

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The aim of this study is to evaluate the effects of hyaluronic acid (HA) on bone healing in human dental sockets.

Detailed Description

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Conditions

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Alveolar Bone Loss

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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hyaluronic acid

Immediately after the extractions, one socket was randomly filled with 1% hyaluronic acid gel.

Group Type EXPERIMENTAL

hyaluronic acid

Intervention Type DRUG

Blood clot

Immediately after the extractions, the other side socket was naturally filled with blood clot.

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type OTHER

Interventions

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hyaluronic acid

Intervention Type DRUG

Placebo

Intervention Type OTHER

Other Intervention Names

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Hyaluronan Sodium hyaluronate

Eligibility Criteria

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Inclusion Criteria

* Orthodontic need for bilateral extraction of lower first premolars

Exclusion Criteria

* Alcoholism, smoking, drug use and abuse of drugs; Systemic diseases: uncontrolled diabetes, blood dyscrasias, kidney or heart failure and osteoporosis; clinical or radiographic signs of pathological processes in the bone;
Minimum Eligible Age

14 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Federal University of Minas Gerais

OTHER

Sponsor Role lead

Responsible Party

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Carlos Eduardo Pinto de Alcântara

MSc,PhD Student, Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Anderson Ferreira, Professor

Role: STUDY_DIRECTOR

Instituto de Ciências Biológicas - Universidade Federal de Minas Gerais

Other Identifiers

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CAAE: 0328.0.203.000-10

Identifier Type: -

Identifier Source: org_study_id

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