Effect of Walking on Brain Fuel Consumption in Mild Alzheimer's Disease

NCT ID: NCT02708485

Last Updated: 2018-10-16

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 15 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2009-04-30
• Study Completion Date: 2017-07-31

Brief Summary

The aim of this study is to evaluate the effect of a 3-month walking program on brain energy metabolism in patient with mild Alzheimer's disease (AD). Two groups of sedentary patients with mild AD are followed and compared over a 3-month period of time: Control (non-active) and walking (from 15 to 45 minutes of exercise on a treadmill, 3 times a week for 12 weeks) groups. All the participants are evaluated on their cognition, brain volumes (MRI) and brain fuel consumption (PET scan with 18-FDG and 11C-AcAc) at the beginning and at the end of the study.

Conditions

Alzheimer's Disease

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Control group

No intervention

Group Type: NO_INTERVENTION

No interventions assigned to this group

Physical exercise

A 3-month walking program (3 times a week for 12 weeks) on treadmill supervised by a physiotherapist. Duration of the exercise is progressively increased from 15 min to 45 min over a 6-week period and the intensity of the exercise is moderate (a 12-13 score on Borg scale).

Group Type: EXPERIMENTAL

Physical exercise

Intervention Type: OTHER

A 3-month walking program (3 times a week for 12 weeks) on treadmill supervised by a physiotherapist. Duration of the exercise is progressively increased from 15 min to 45 min over a 6-week period and the intensity of the exercise is moderate (a 12-13 score on Borg scale).

Interventions

Physical exercise

A 3-month walking program (3 times a week for 12 weeks) on treadmill supervised by a physiotherapist. Duration of the exercise is progressively increased from 15 min to 45 min over a 6-week period and the intensity of the exercise is moderate (a 12-13 score on Borg scale).

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Diagnosis of mild Alzheimer's disease (NINCDS-ADRDA criteria)
• Taking cholinesterase inhibitors
• Sedentary
• Ability to do physical exercise

Exclusion Criteria

• Parkinson disease
• Down syndrome
• Epilepsy or concussion
• Drug or alcohol abuse
• Past psychiatric history
• Vitamin B12 Deficiency
• Uncontrolled diabetes or thyroid function

• Minimum Eligible Age: 40 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Université de Sherbrooke

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Nancy Paquet, MD

Role: PRINCIPAL_INVESTIGATOR

Estrie University Integrated Health and Social Services Center - University Hospital of Sherbrooke

Stephen Cunnane, PhD

Role: PRINCIPAL_INVESTIGATOR

CDRV - CSSS-IUGS - CIUSSS de l'Estrie - CHUS

Locations

Research Centre on Aging (CSSS-IUGS - CIUSSS de l'Estrie - CHUS)

Sherbrooke, Quebec, Canada

Countries

Canada

Provided Documents

Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

09-043

Identifier Type: -

Identifier Source: org_study_id