Evaluation of Long-Term Safety of Pirfenidone (Esbriet) in Participants With Idiopathic Pulmonary Fibrosis (IPF)

NCT ID: NCT02699879

Last Updated: 2017-04-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

1009 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-02-16

Study Completion Date

2016-09-15

Brief Summary

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This single arm, post-authorisation study is designed to evaluate the long-term safety of pirfenidone in participants with IPF. The enrolment of participants will be completed within approximately 24 months. Participants will receive pirfenidone according to the physician discretion and will be followed for 2 years. Treating physicians will collect pre-specified data at the baseline and every 3 months thereafter, for the duration of the participants' participation in study.

Detailed Description

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Conditions

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Idiopathic Pulmonary Fibrosis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Pirfenidone

Participants will receive pirfenidone orally according to the physician discretion.

Pirfenidone

Intervention Type DRUG

Pirfenidone will be administered according to the physician discretion as part of standard care.

Interventions

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Pirfenidone

Pirfenidone will be administered according to the physician discretion as part of standard care.

Intervention Type DRUG

Other Intervention Names

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Esbriet

Eligibility Criteria

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Inclusion Criteria

* A clinical decision has been made, prior to study enrolment, to prescribe Esbriet
* Participants who are newly prescribed Esbriet therapy
* Initiation of Esbriet therapy is not more than 30 days prior to study enrolment

Exclusion Criteria

* Participants receiving an investigational agent defined as any drug that has not been approved for marketing for any indication in the country of the participating site
* Participant has received Esbriet therapy 30 days or more prior to current treatment course (e.g., prior participation in clinical trials)
* Participant has any contraindication for the use of Esbriet, according to the current local version of the Summary of Product Characteristics (SPC)
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hoffmann-La Roche

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Clinical Trials

Role: STUDY_DIRECTOR

Hoffmann-La Roche

Locations

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Medical University Graz; Department for Respiratory Diseases

Graz, , Austria

Site Status

LKH Hohenems; Abteilung für Pulmologie

Hohenems, , Austria

Site Status

Medizinische Universitat Innsbruck; Department of Internal Medicine, Pneumology Centre

Innsbruck, , Austria

Site Status

Klinikum Klagenfurt; Abteilung für Pulmologie

Klagenfurt, , Austria

Site Status

St. Johanns-Spital; Abt. Für Lungenkrankungen

Salzburg, , Austria

Site Status

Aarhus University Hospital; Lungemed afd. B

Aarhus, , Denmark

Site Status

Gentofte Hospital, Lungemedicinsk Afdeling

Hellerup, , Denmark

Site Status

Odense Universitetshospital, Lungemedicinsk Afdeling J

Odense, , Denmark

Site Status

Helsinki University Central Hospital; Dep. of Pulmonary Medicine

Helsinki, , Finland

Site Status

Kuopio University Hospital

Kuopio, , Finland

Site Status

Tampere University Hospital; Lung Clinic

Tampere, , Finland

Site Status

Turku University Hospital; Dept of Pulmonology

Turku, , Finland

Site Status

CHU Angers,Service de Pneumologie

Angers, , France

Site Status

Hopital Jean Minjoz; Pneumologie

Besançon, , France

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Hopital Avicenne; Pneumologie

Bobigny, , France

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Hopital de La Cavale Blanche; Service de Medecine Interne & de Pneumologie

Brest, , France

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Hopital Louis Pradel; Pneumologie

Bron, , France

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Hopital Cote De Nacre; Pneumologie

Caen, , France

Site Status

Chu Site Du Bocage;Pneumologie

Dijon, , France

Site Status

CHU de Grenoble; Medecine Aigue Spec

Grenoble, , France

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Hopital Calmette; Pneumologie

Lille, , France

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CHU de Limoges

Limoges, , France

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Hopital Nord AP-HM

Marseille, , France

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Hopital Nord; Pneumologie

Marseille, , France

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CHU Montpellier

Montpellier, , France

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Hopital Saint Louis

Paris, , France

Site Status

Hopital Bichat Claude Bernard ; Service de Pneumologie

Paris, , France

Site Status

HEGP; Pneumologie

Paris, , France

Site Status

Hopital Tenon;Pneumologie

Paris, , France

Site Status

Hôpital Haut-Lévêque - CHU de Bordeaux - Groupe Hospitalier Sud

Pessac, , France

Site Status

Hopital De La Maison Blanche;Maladies Respiratoires

Reims, , France

Site Status

Hopital de Pontchaillou; Service de Pneumologie

Rennes, , France

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Chu De Strasbourg; Hopital Civil

Strasbourg, , France

Site Status

Hopital Larrey; Pneumologie

Toulouse, , France

Site Status

Chu De Tours,Service de Pneumologie

Tours, , France

Site Status

Zentralklinik Bad Berka GmbH; Pneumologie

Bad Berka, , Germany

Site Status

Lungenklinik Ballenstedt/Harz gGmbH Lungenklinik Ballenstedt/Harz gGmbH

Ballenstedt, , Germany

Site Status

Evang. Lungenklinik Berlin Klinik für Pneumologie

Berlin, , Germany

Site Status

Charite - Universitätsmedizin Berlin; Campus Virchow-Klinikum, Med. Klinik m. S. Infekt und Pneumo

Berlin, , Germany

Site Status

Gemeinschaftskrankenhaus Havelhöhe Klinik f.Innere Medizin Kardiologie Pneumologie

Berlin, , Germany

Site Status

HELIOS Klinikum Emil von Behring Klinik f.Pneumologie Onkologie u.Infektiologie

Berlin, , Germany

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Berufsgenossenschaftliches Uni-Klinikum Bergmannsheil GmbH

Bochum, , Germany

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Klinkum Coburg GmbH

Coburg, , Germany

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Fachkrankenhaus Coswig GmbH Zentrum f.Pneumologie Beatmungsmedizin Thorax-u.Gefäßchirurgie

Coswig, , Germany

Site Status

Carl-Thiem-Klinik Cottbus; Medizinische Klinik

Cottbus, , Germany

Site Status

Klinik Donaustauf Zentrum für Pneumologie

Donaustauf, , Germany

Site Status

Ruhrlandklinik Lungenzentrum der UNI Essen Abt.Pneumologie-Allergologie

Essen, , Germany

Site Status

Klinikum Esslingen; Klinik für Kardiologie, Angiologie und Pneumologie

Esslingen am Neckar, , Germany

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Klinik Maingau

Frankfurt, , Germany

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Studienzentrum/Praxis Dr. Keller Frankfurt

Frankfurt, , Germany

Site Status

IFS - Interdisziplinäres Facharztzentrum; Institut für klinische Forschung Pneumologie

Frankfurt am Main, , Germany

Site Status

Universitätsklinikum Freiburg, Abteilung Pneumologie

Freiburg im Breisgau, , Germany

Site Status

Klinik Schillerhöhe Zentrum f.Pneumologie u.Thoraxchirurgie

Gerlingen, , Germany

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Universitätsklinikum Standort Gießen Medizinische Klinik II u. Poliklinik Innere Med./Pneumologie

Giessen, , Germany

Site Status

Universitätsmedizin Greifswald Klinik für Innere Medizin B und Poliklinik

Greifswald, , Germany

Site Status

LungenClinic Grosshansdorf GmbH; Zentrum fur Pneumologie und Thoraxchirurgie

Großhansdorf, , Germany

Site Status

Medizinische Hochschule Hannover

Hanover, , Germany

Site Status

KRH Klinikum Oststadt-Heidehaus; Pneumologie, Intensiv- und Schlafmedizin

Hanover, , Germany

Site Status

Lungenklinik Hemer; Abt. Pneumologie

Hemer, , Germany

Site Status

Universitaetsklinikum des Saarlandes; Innere Medizin V

Homburg/Saar, , Germany

Site Status

Fachklinik für Lungenerkrankungen

Immenhausen, , Germany

Site Status

Universitätsklinikum Jena; Medizinische Klinik I

Jena, , Germany

Site Status

Universitaetsklinikum Schleswig-Holstein, Campus Kiel

Kiel, , Germany

Site Status

Universität Leipzig; Medizinische Klinik und Poliklinik I, Abteilung Pneumologie

Leipzig, , Germany

Site Status

Lungenklinik Lostau gGmbH; Klinik für Pneumologie II

Lostau, , Germany

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Klinik Löwenstein gGmbH Medizinische Klinik II

Löwenstein, , Germany

Site Status

Universitätsklinikum Magdeburg Klinik für Kardiologie Angiologie u.Pneumologie

Magdeburg, , Germany

Site Status

Klinikum der Universität München; Campus Großhadern; Med. Klinik und Poliklinik V

München, , Germany

Site Status

Klinikum Nuernberg Nord; Medizinische Klinik 3, Schwerpunkt Pneumologie, Allergologie, Schlafmedizin

Nuremberg, , Germany

Site Status

RoMed Klinikum Rosenheim, Medizinische Klinik III

Rosenheim, , Germany

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Krankenhaus Bethanien gGmbH

Solingen, , Germany

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Krankenhaus vom Roten Kreutz; Klinik fuer Pneumologie

Stuttgart, , Germany

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Johanniter-Krankenhaus im Fläming Treuenbrietzen GmbH; Fachklinik Pneumologie/ Thoraxchirurgie

Treuenbrietzen, , Germany

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Fachkliniken Wangen Medizinische Klinik

Wangen, , Germany

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Universitätsklinikum Würzburg, Kinderklinik u. Poliklinik

Würzburg, , Germany

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Cork University Hospital

Cork, , Ireland

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Mater Misecordiae University Hospital

Dublin, , Ireland

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St Vincents University Hospital

Dublin, , Ireland

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Galway University Hospital; Department of Respiratory Medicine

Galway, , Ireland

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Ospedale Morgagni-Pierantoni; U.O. Pneumologia

Forlì, Emilia-Romagna, Italy

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A.O. Universitaria Policlinico Di Modena; DIP. Malattie Dell'apparato Respiratorio

Modena, Emilia-Romagna, Italy

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Universita' Degli Studi Di Milano Bicocca, Ospedale Vecchio; facolta di medicina e chirurgia, dipart

Monza, Lombardy, Italy

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A.O. Universitaria San Luigi Gonzaga di Orbassano; Ambulatorio per le Malattie Rare del Polmone

Orbassano (TO), Piedmont, Italy

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Azienda Ospedaliero Universitaria Di Sassari; Clinica Pneumologica

Sassari, Sardinia, Italy

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Azienda Ospedaliera Universitaria Careggi

Florence, Tuscany, Italy

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A.O. Univ. Senese Policlinico S. Maria alle Scotte; UOC Malattie Resepiratorie e Trapianto Polmonare

Siena, Tuscany, Italy

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Haukeland Hospital - University Of Bergen: Department of Resp Med

Bergen, , Norway

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Oslo University Hospital Rikshospitalet; Lungeavdelingen

Oslo, , Norway

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St. Olav's Hospital; Lung Clinic

Trondheim, , Norway

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Karolinska Universitetssjukhuset Solna; Lung Allergikliniken

Stokholm, Solna, , Sweden

Site Status

Akademiska Sjukhuset; Lungmedicinska Kliniken

Uppsala, , Sweden

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Southmead Hospital; Respiratory Department

Bristol, , United Kingdom

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Papworth Hospital NHS Foundation Trust; Respiratory Department

Cambridge, , United Kingdom

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Castle Hill Hospital; Respiratory Medicine

Cottingham, , United Kingdom

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Royal Devon and Exeter Hospital (Wonford)

Exeter, , United Kingdom

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Southampton General Hospital; Respiratory Department

Hampshire, , United Kingdom

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Glenfield Hospital

Leicester, , United Kingdom

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University Hospital Aintree; Pulmonary Vascular Diseases Unit

Liecester, , United Kingdom

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University College London Hospital; Respiratory Medicine

London, , United Kingdom

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Royal Brompton Hospital; Respiratory Department

London, , United Kingdom

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St. Mary'S Hospital; Dept of Medicine

London, , United Kingdom

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Wythenshawe Hospital

Manchester, , United Kingdom

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Nottingham University Hospitals City Campus

Nottingham, , United Kingdom

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Queen Alexandra Hospital; Respiratory Centre

Portsmouth, , United Kingdom

Site Status

Northern General Hospital

Sheffield, , United Kingdom

Site Status

University Hospital of North Staffordshire; ILD Clinic

Stoke-on-Trent, , United Kingdom

Site Status

Countries

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Austria Denmark Finland France Germany Ireland Italy Norway Sweden United Kingdom

References

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Behr J, Nathan SD, Costabel U, Albera C, Wuyts WA, Glassberg MK, Haller H Jr, Alvaro G, Gilberg F, Samara K, Lancaster L. Efficacy and Safety of Pirfenidone in Advanced Versus Non-Advanced Idiopathic Pulmonary Fibrosis: Post-Hoc Analysis of Six Clinical Studies. Adv Ther. 2023 Sep;40(9):3937-3955. doi: 10.1007/s12325-023-02565-3. Epub 2023 Jun 30.

Reference Type DERIVED
PMID: 37391667 (View on PubMed)

Other Identifiers

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PIPF-025

Identifier Type: OTHER

Identifier Source: secondary_id

WB29908

Identifier Type: -

Identifier Source: org_study_id

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