Chronic Inflammation After Obesity Surgery

NCT ID: NCT02697695

Last Updated: 2018-07-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-10-31

Study Completion Date

2016-02-29

Brief Summary

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To evaluate the impact of obesity surgery on chronic inflammation.

Detailed Description

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A retrospective study to compare the impact of laparoscopic sleeve gastrectomy (LSG), laparoscopic Roux-en Y- gastric bypass (LRYGB) and laparoscopic omega-loop gastric bypass (LOLGB) on chronic inflammation and metabolic syndrome.

Conditions

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Obesity

Study Design

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Observational Model Type

OTHER

Study Time Perspective

RETROSPECTIVE

Study Groups

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laparoscopic sleeve gastrectomy

patients who underwent laparoscopic sleeve gastrectomy (LSG) due to obesity and/or metabolic syndrome

Laboratory Examination

Intervention Type OTHER

Laboratory Examination before, 1 month, 3 month, 6 month and up to 12 month after LSK, LRNYGB, LOLGB

laparoscopic Roux-en-Y- gastric bypass

patients who underwent laparoscopic Roux-en-Y- gastric bypass (LRYGB) due to obesity and/or metabolic syndrome

Laboratory Examination

Intervention Type OTHER

Laboratory Examination before, 1 month, 3 month, 6 month and up to 12 month after LSK, LRNYGB, LOLGB

laparoscopic omega-loop gastric bypass

patients who underwent laparoscopic omega-loop gastric bypass (LOLGB) due to obesity and/or metabolic syndrome

Laboratory Examination

Intervention Type OTHER

Laboratory Examination before, 1 month, 3 month, 6 month and up to 12 month after LSK, LRNYGB, LOLGB

Interventions

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Laboratory Examination

Laboratory Examination before, 1 month, 3 month, 6 month and up to 12 month after LSK, LRNYGB, LOLGB

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* BMI \> 35kg/m² and obesity-related disease or BMI \> 40kg/m²

Exclusion Criteria

* acute inflammation during laboratory examination
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Sana Klinikum Offenbach

OTHER

Sponsor Role lead

Responsible Party

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Sonja Chiappetta, MD

Dr. Sonja Chiappetta

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Rudolf Weiner, MD

Role: STUDY_CHAIR

Sana Klinikum Offenbach, Department of Obesity and Metabolic Surgery

References

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Hotamisligil GS. Inflammation and metabolic disorders. Nature. 2006 Dec 14;444(7121):860-7. doi: 10.1038/nature05485.

Reference Type RESULT
PMID: 17167474 (View on PubMed)

Nijhuis J, Rensen SS, Slaats Y, van Dielen FM, Buurman WA, Greve JW. Neutrophil activation in morbid obesity, chronic activation of acute inflammation. Obesity (Silver Spring). 2009 Nov;17(11):2014-8. doi: 10.1038/oby.2009.113. Epub 2009 Apr 23.

Reference Type RESULT
PMID: 19390527 (View on PubMed)

Morshed G, Fathy SM. Impact of post-laparoscopic sleeve gastrectomy weight loss on C-reactive protein, lipid profile and CA-125 in morbidly obese women. Wideochir Inne Tech Maloinwazyjne. 2016 Jan;10(4):521-6. doi: 10.5114/wiitm.2015.56480. Epub 2015 Dec 15.

Reference Type RESULT
PMID: 26865887 (View on PubMed)

Wellen KE, Hotamisligil GS. Inflammation, stress, and diabetes. J Clin Invest. 2005 May;115(5):1111-9. doi: 10.1172/JCI25102.

Reference Type RESULT
PMID: 15864338 (View on PubMed)

Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, Nakajima Y, Nakayama O, Makishima M, Matsuda M, Shimomura I. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest. 2004 Dec;114(12):1752-61. doi: 10.1172/JCI21625.

Reference Type RESULT
PMID: 15599400 (View on PubMed)

Chiappetta S, Schaack HM, Wolnerhannsen B, Stier C, Squillante S, Weiner RA. The Impact of Obesity and Metabolic Surgery on Chronic Inflammation. Obes Surg. 2018 Oct;28(10):3028-3040. doi: 10.1007/s11695-018-3320-y.

Reference Type DERIVED
PMID: 29876839 (View on PubMed)

Other Identifiers

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FF 145/2015

Identifier Type: -

Identifier Source: org_study_id

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