Obesity-related Inflammation in Patients Prior to and After Bariatric Surgery

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

43 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-06-30

Study Completion Date

2016-10-28

Brief Summary

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This study investigates the chronic long-term health condition of obesity and its effect on neutrophil function and the inflammatory response

Detailed Description

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Inflammation is a central component of the immune response. In its acute form it aids the transition from disease to health via the activation of numerous immune cells, enabling them to reach the site of infection/injury and orchestrate themselves to combat pathogens, facilitating resolution and repair to restore the host to health. However, chronic inflammation is deleterious to the host and differs from the "classical" acute inflammatory process in that the inflammation is not necessarily so readily obvious and is not self-limiting; rather, the immune system is in a constant state of low-grade activation and when challenged by pathogenic or sterile injury the response is heightened, resulting in prolonged tissue damage and a failure of efficient resolution mechanisms.

Neutrophils are important mediators of acquired innate immune responses but may also contribute to the pathogenesis of chronic inflammatory diseases. Neutrophils are heavily involved in antimicrobial defence; their primary role is the localisation and elimination of pathogenic microorganisms. This, combined with their relatively short lifespan, has resulted in a traditional view of them as limited "kamikaze" cells. However, as detailed here, neutrophils have been shown to act with complexity and sophistication, orchestrating the immune/inflammatory response but also inadvertently contributing to tissue damage in different disease states. This study investigates the chronic long-term health condition of obesity and its effect on neutrophil function and the inflammatory response

Conditions

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Obesity Morbid Obesity

Keywords

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gastric bypass Obesity Morbid obesity Matched Healthy Controls

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Patients with a BMI over 40

Participants were aged between 27-65 years, BMI \>40 , Co-Morbidities associated with obesity including sleep apnoea, hypertension, depression, hypercholesterolaemia and type 2 diabetes, Undergoing Gastric Band surgery

No interventions assigned to this group

Lean, healthy individuals

Participants were aged between 27-65 years, BMI\<28 , Systemically healthy, taking no prescribed medication

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* BMI \>40
* Undergoing Gastric Band surgery

Exclusion Bariatric Participants Criteria:

* Undergoing alternative weight loss surgery
* BMI\<40
* Smoking
* Pregnancy

Exclusion Criteria

* BMI over 27
* pregnancy
* smoking
* evidence of systemic disease
* use of medications/vitamin supplements.

Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Responsible Party

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Responsibility Role SPONSOR

Other Identifiers

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ERN_13-0355

Identifier Type: -

Identifier Source: org_study_id