Association Between Vitamin D Deficiency and Preeclampsia: A Case Control Study

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

90 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-06-30

Study Completion Date

2016-01-31

Brief Summary

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To find out if lower levels of vitamin D is more prevalent in preeclamptic women

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Detailed Description

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Conditions

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Pre-Eclampsia

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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preeclamptic group

1. Blood pressure: greater than or equal to 140 mmHg systolic or greater than or equal to 90 mmHg diastolic on two occasions at least 4 hours apart after 20 weeks of gestation (Roberts et al., 2013).
2. Proteinuria: protein/creatinine ratio greater than or equal to 0.3
3. In the absence of proteinuria, a new-onset hypertension with new onset of the following:

* thrombocytopenia: platelet count less than 100.000/microliter
* renal insufficiency: serum creatinine greater than 1.1 mg/dl
* impaired liver function: elevated concentration of liver transaminases
* pulmonary edema
* cerebral or visual symptoms
* Severe right upper quadrant or epigastric pain unresponsive to medication.

No interventions assigned to this group

non preeclamptic group

All are normotensive with blood pressure \<140/90 with no proteinuria.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Parity: primigravida.
* Age: 18 - 35 years.
* Singleton pregnancy.
* Gestational age: 36-40 weeks.
* No past history of any medical disorder and with no other medical complications during pregnancy

Exclusion Criteria

* Women with preexisting medical conditions like rheumatoid arthritis, thyroid, hepatic or renal failure, metabolic bone disease, diabetes mellitus, malabsorption and lupus.
* History of intake of medications influencing bone, vitamin D or calcium metabolism e.g. antiepileptic, theophylline, antitubercular drugs in the last 6 months.
* Women with multiple pregnancy.
* Women with congenital fetal malformation.
* Women with known thrombophilia

Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No