Nebulized Beclometasone Dipropionate Improves Nasal Patency in Children With Allergic Rhinitis

NCT ID: NCT02646904

Last Updated: 2017-11-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

68 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-05-31

Study Completion Date

2017-07-31

Brief Summary

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The purpose of this study is to examine in children with persistent AR the effect of the topically applied beclomethasone in comparison with cetirizine on nasal patency evaluated by acoustic rhinometry and subjective nasal symptoms.

Detailed Description

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Conditions

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Allergic Rhinitis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Beclometasone Dipropionate (BDP)

Standard dose (400 µg/daily as 100 µg 1 spray nos bid) of Nasal Beclomethasone Dipropionate for 21 days.

Group Type EXPERIMENTAL

Nasal Beclomethasone Dipropionate

Intervention Type DRUG

Standard dose (400 µg/daily as 100 µg 1 spray nos bid) of nebulized Beclomethasone Dipropionate nasal spray for 21 days.

CERCHIO 10 mg/ml OS

For Children \< 12 years old 10 drops die (5 mg die) for 21 days. For Children \> 12 years old 20 drops die (10 mg die) for 21 days.

Group Type ACTIVE_COMPARATOR

CERCHIO 10 mg/ml OS

Intervention Type DRUG

For Children \< 12 years old 10 drops die (5 mg die) for 21 days. For Children \> 12 years old 20 drops die (10 mg die) for 21 days.

Interventions

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Nasal Beclomethasone Dipropionate

Standard dose (400 µg/daily as 100 µg 1 spray nos bid) of nebulized Beclomethasone Dipropionate nasal spray for 21 days.

Intervention Type DRUG

CERCHIO 10 mg/ml OS

For Children \< 12 years old 10 drops die (5 mg die) for 21 days. For Children \> 12 years old 20 drops die (10 mg die) for 21 days.

Intervention Type DRUG

Other Intervention Names

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NBDP

Eligibility Criteria

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Inclusion Criteria

* children 6-16 years of age with a history of AR in the previous year
* T5SS: ≥5 in the last week before enrollment

Exclusion Criteria

* asthma symptoms
* acute upper respiratory infections
* anatomic nasal defects (ie, septum deviation), or nasal polyps
* use in the past 4 weeks of nasal or oral corticosteroids, nasal or oral decongestants, antihistamines.
Minimum Eligible Age

6 Years

Maximum Eligible Age

16 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Stefania La Grutta, MD

OTHER

Sponsor Role lead

Responsible Party

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Stefania La Grutta, MD

MD, Senior Researcher, Coordinator of Pediatric Allergy and Asthma Research Group. Institute of Biomedicine and Molecular Immunology, IBIM, National Research Council of Palermo, Italy.

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council

Palermo, Sicily, Italy

Site Status

Institute of Biomedicine and Molecular Immunology, IBIM

Palermo, , Italy

Site Status

Countries

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Italy

Other Identifiers

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9-2015

Identifier Type: -

Identifier Source: org_study_id