Characteristics of Culprit Lesion and Changes in Plaque Composition. A Dual Energy Cardiac CT Study
NCT ID: NCT02639962
Last Updated: 2017-06-01
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
135 participants
OBSERVATIONAL
2014-09-30
2017-09-30
Brief Summary
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In this study the investigators will investigate culprit lesion in patients with NSTEMI and the ability of cardiac CT with dual energy computed tomography (DECT) scanning to describe and identify plaques that may be vulnerable. The investigators will also describe changes in characteristic in both stable and unstable plaques during 1 year follow up of NSTEMI and a matching group of stable angina pectoris (SAP) patients.
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Detailed Description
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Patients with SAP undergo a baseline DECT similar to NSTEMI group. Because the expected change in coronary plaques in SAP group is minimal, there is no need for follow up at 2 month.
Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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NSTEMI
patients hospitalized with NSTEMI diagnosed according to the national Danish guidelines, and are scheduled to coronary angiography.
Cardiac CT
Cardiac CT before the CAG, and follow up after 2 month and 12 month
patients with stable angina pectoris
Patients in this group have stable angina symptoms and had verified plaques by earlier CAG or Cardiac CT
Cardiac CT
Cardiac CT before the CAG, and follow up after 2 month and 12 month
Interventions
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Cardiac CT
Cardiac CT before the CAG, and follow up after 2 month and 12 month
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Known allergy-like reactions to contrast or Claustrophobia
* Atrial fibrillation or significant arrhythmia judged to potentially limit quality of CT
* Known renal failure/insufficiency or s-creatinin\> 140 µmol/L.
* Severe/symptomatic thyrotoxicosis
* pacemaker
18 Years
90 Years
ALL
No
Sponsors
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Odense University Hospital
OTHER
Responsible Party
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Hussam Mahmoud Sheta
MD
Principal Investigators
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Kenneth Egstrup
Role: STUDY_DIRECTOR
Odense University Hospital, Svendborg Research Department
Locations
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Department of Medical Research, OUH, Svendborg
Svendborg, , Denmark
Countries
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Central Contacts
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Facility Contacts
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Hussam Sheta, MD
Role: primary
Other Identifiers
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Challenge
Identifier Type: -
Identifier Source: org_study_id
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