Assessment of the Handling Experience With the BI 695501 Autoinjector in Patients With Rheumatoid Arthritis Followed by an Extension Phase Using BI 695501 Prefilled Syringe

NCT ID: NCT02636907

Last Updated: 2018-07-10

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

View full results

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

77 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-01-06

Study Completion Date

2017-06-29

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This is an open-label, phase II study of BI 695501 to assess handling experience of patients with Rheumatoid Arthritis using an autoinjector. The extension phase is to provide patients with additional exposure to BI 695501 and to enhance the safety database for this compound.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Arthritis, Rheumatoid

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

BI 695501

Group Type EXPERIMENTAL

BI 695501 Autoinjector

Intervention Type DRUG

BI 695501 Prefilled syringe

Intervention Type DRUG

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

BI 695501 Autoinjector

Intervention Type DRUG

BI 695501 Prefilled syringe

Intervention Type DRUG

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Moderately to severely active Rheumatoid arthritis (RA) for at least 6 months, which is not adequately controlled by non-biologics DMARDs.
* No contraindications to anti-Tumor necrosis factor (TNF) agents.
* Either biologics naive or biologics-experienced but with no experience of self-administration medication using autoinjector or pen.

Exclusion Criteria

* Experience with self-administration of medication using an autoinjector or pen.
* American College of Rheumatology functional Class IV or wheelchair/ bed bound.
* Primary or secondary immunodeficiency.
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Boehringer Ingelheim

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Boehringer Ingelheim

Role: STUDY_CHAIR

Boehringer Ingelheim

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Inland Rheumatology Clinical Trials, Inc.

Upland, California, United States

Site Status

Lovelace Scientific Resources, Incorporated

Venice, Florida, United States

Site Status

Klein and Associates, M.D., P.A.

Cumberland, Maryland, United States

Site Status

Clinical Pharmacology Study Group

Worcester, Massachusetts, United States

Site Status

Albuquerque Center For Rheumatology

Albuquerque, New Mexico, United States

Site Status

Metroplex Clinical Research Center

Dallas, Texas, United States

Site Status

Rheumatology Clinic Of Houston, P.A.

Houston, Texas, United States

Site Status

Arthritis & Osteoporosis Associates LLP

Lubbock, Texas, United States

Site Status

Heartland Research Associates, LLC

Nassau Bay, Texas, United States

Site Status

Gabinet Internistyczno-Reumatologiczny Piotr Adrian Klimiuk

Bialystok, , Poland

Site Status

Szpital Uniwersytecki nr 2 im.dr J. Biziela

Bydgoszcz, , Poland

Site Status

Wojewodzki Szpital Zespolony w Elblagu

Elblag, , Poland

Site Status

Medica Pro Familia Spolka Akcyjna, Oddzial w Gdyni

Gdynia, , Poland

Site Status

Medical Centre Pratia Katowice I

Katowice, , Poland

Site Status

Medical Centre Pratia Krakow

Krakow, , Poland

Site Status

Specialist Center ALL-MED, Krakow

Krakow, , Poland

Site Status

Niepubliczny ZOZ, "Nasz Lekarz", Lekarzy Rodzinnych z

Torun, , Poland

Site Status

Medical Centre Pratia Warszawa

Warsaw, , Poland

Site Status

Wojewodzki Szpital Specjalistyczny we Wroclawiu

Wroclaw, , Poland

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States Poland

References

Explore related publications, articles, or registry entries linked to this study.

Cohen S, Klimiuk PA, Krahnke T, Assudani D. Successful administration of BI 695501, an adalimumab biosimilar, using an autoinjector (AI): results from a Phase II open-label clinical study (VOLTAIRE(R)-RL). Expert Opin Drug Deliv. 2018 Jun;15(6):545-548. doi: 10.1080/17425247.2018.1472572. Epub 2018 May 15.

Reference Type DERIVED
PMID: 29764238 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

2015-003030-27

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

1297.11

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.