A Study to Evaluate the Safe and Effective Use of the Prefilled Safety Syringe or the Auto-injector for the Subcutaneous Self-injection of Bimekizumab Solution by Subjects With Active Psoriatic Arthritis

NCT ID: NCT04109976

Last Updated: 2023-11-30

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

214 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-08-13

Study Completion Date

2020-11-13

Brief Summary

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The purpose of the study is to evaluate for each self-injecting device presentation the ability of subjects with psoriatic arthritis (PsA) to safely and effectively self-inject bimekizumab at study start and 4 weeks after training in self-injection technique using the bimekizumab safety syringe (SS) or the bimekizumab auto-injector (AI).

Detailed Description

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Conditions

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Psoriatic Arthritis

Keywords

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Psoriatic Arthritis PsA Auto-Injector Bimekizumab

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Bimekizumab-SS

Study participants randomized to this arm will receive assigned bimekizumab dose regimen using the prefilled safety syringe (SS).

Group Type EXPERIMENTAL

Bimekizumab

Intervention Type DRUG

Study participants will receive bimekizumab at pre-specified time points.

Bimekizumab-AI

Study participants randomized to this arm will receive assigned bimekizumab dose regimen using the auto-injector (AI).

Group Type EXPERIMENTAL

Bimekizumab

Intervention Type DRUG

Study participants will receive bimekizumab at pre-specified time points.

Interventions

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Bimekizumab

Study participants will receive bimekizumab at pre-specified time points.

Intervention Type DRUG

Other Intervention Names

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UCB4940 BKZ

Eligibility Criteria

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Inclusion Criteria

* Subject is considered reliable and capable of adhering to the DV0004 protocol (eg, able to understand and complete questionnaires, able to use investigational self-injecting device presentations according to the instructions for use (IFU), and able to adhere to the visit schedule) according to the judgment of the Investigator
* Subject is willing to self-inject
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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UCB Biopharma SRL

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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UCB Cares

Role: STUDY_DIRECTOR

001 844 599 2273 (UCB)

Locations

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Dv0004 50024

Boise, Idaho, United States

Site Status

Dv0004 50028

Lexington, Kentucky, United States

Site Status

Dv0004 50023

Baton Rouge, Louisiana, United States

Site Status

Dv0004 50015

Hagerstown, Maryland, United States

Site Status

Dv0004 50026

Wheaton, Maryland, United States

Site Status

Dv0004 50019

Lansing, Michigan, United States

Site Status

Dv0004 50016

St Louis, Missouri, United States

Site Status

Dv0004 50005

Freehold, New Jersey, United States

Site Status

Dv0004 50029

Albuquerque, New Mexico, United States

Site Status

Dv0004 50010

Brooklyn, New York, United States

Site Status

Dv0004 50125

Charlotte, North Carolina, United States

Site Status

Dv0004 50031

Salisbury, North Carolina, United States

Site Status

Dv0004 50040

Dayton, Ohio, United States

Site Status

Dv0004 50020

Duncansville, Pennsylvania, United States

Site Status

Dv0004 50006

Wyomissing, Pennsylvania, United States

Site Status

Dv0004 50008

Johnston, Rhode Island, United States

Site Status

Dv0004 50001

Jackson, Tennessee, United States

Site Status

Dv0004 50036

Mesquite, Texas, United States

Site Status

Dv0004 50009

Waco, Texas, United States

Site Status

Dv0004 50050

Beckley, West Virginia, United States

Site Status

Dv0004 40061

Brno, , Czechia

Site Status

Dv0004 40009

Pardubice, , Czechia

Site Status

Dv0004 40063

Prague, , Czechia

Site Status

Dv0004 40066

Prague, , Czechia

Site Status

Dv0004 40010

Uherské Hradiště, , Czechia

Site Status

Dv0004 40012

Zlín, , Czechia

Site Status

Dv0004 40029

Hamburg, , Germany

Site Status

Dv0004 40079

Szentes, , Hungary

Site Status

Dv0004 40038

Elblag, , Poland

Site Status

Dv0004 40088

Elblag, , Poland

Site Status

Dv0004 40096

Gdynia, , Poland

Site Status

Dv0004 40042

Krakow, , Poland

Site Status

Dv0004 40092

Krakow, , Poland

Site Status

Dv0004 40037

Lublin, , Poland

Site Status

Dv0004 40091

Nowa Sól, , Poland

Site Status

Dv0004 40044

Poznan, , Poland

Site Status

Dv0004 40118

Torun, , Poland

Site Status

Dv0004 40041

Warsaw, , Poland

Site Status

Dv0004 40097

Warsaw, , Poland

Site Status

Dv0004 40098

Warsaw, , Poland

Site Status

Dv0004 40039

Wroclaw, , Poland

Site Status

Dv0004 40043

Wroclaw, , Poland

Site Status

Dv0004 20005

Moscow, , Russia

Site Status

Dv0004 20013

Petrozavodsk, , Russia

Site Status

Dv0004 20004

Saint Petersburg, , Russia

Site Status

Dv0004 20014

Ulyanovsk, , Russia

Site Status

Dv0004 20015

Yaroslavl, , Russia

Site Status

Countries

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United States Czechia Germany Hungary Poland Russia

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Related Links

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Other Identifiers

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2018-004725-86

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

DV0004

Identifier Type: -

Identifier Source: org_study_id