Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
60 participants
INTERVENTIONAL
2016-04-30
2017-01-31
Brief Summary
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Detailed Description
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Animal and first human studies provided evidence that resveratrol might serve as an easy, cost-effective option to develop novel prevention and treatment strategies against age-associated cognitive decline. To test this hypothesis, the researchers study general brain structure and function on healthy older individuals (\> 60years old).
Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
TRIPLE
Study Groups
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resveratrol supplementation
Dietary Supplement: Resveratrol
resveratrol supplementation
6 months of resveratrol supplementation
placebo supplementation
Dietary Supplement: Placebo
Placebo
6 months of placebo intake
Interventions
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resveratrol supplementation
6 months of resveratrol supplementation
Placebo
6 months of placebo intake
Eligibility Criteria
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Inclusion Criteria
* older than 60 years old
* normal to overweight participants (BMI: 22-40 kg/sqm)
Exclusion Criteria
* Psychiatric diseases
* severe untreated internal diseases
* diabetes
* younger than 60 years
* BMI \< 22 or \>40
60 Years
ALL
Yes
Sponsors
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University of Leipzig
OTHER
Evolva SA
INDUSTRY
Max Planck Institute for Human Cognitive and Brain Sciences
OTHER
Responsible Party
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Principal Investigators
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Arno Villringer, Prof.
Role: STUDY_CHAIR
Max Planck Institute for Human Cognitive and Brain Sciences
Arno Villringer
Role: STUDY_DIRECTOR
Max Planck Institute for Human Cognitive and Brain Sciences
Veronica Witte
Role: STUDY_DIRECTOR
Max Planck Institute for Human Cognitive and Brain Sciences
Veronica Witte
Role: PRINCIPAL_INVESTIGATOR
Max Planck Institute for Human Cognitive and Brain Sciences
Locations
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Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences
Leipzig, , Germany
Countries
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References
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Huhn S, Beyer F, Zhang R, Lampe L, Grothe J, Kratzsch J, Willenberg A, Breitfeld J, Kovacs P, Stumvoll M, Trampel R, Bazin PL, Villringer A, Witte AV. Effects of resveratrol on memory performance, hippocampus connectivity and microstructure in older adults - A randomized controlled trial. Neuroimage. 2018 Jul 1;174:177-190. doi: 10.1016/j.neuroimage.2018.03.023. Epub 2018 Mar 13.
Study Documents
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Document Type: Statistical Analysis Plan
View DocumentDocument Type: Statistical Analysis Plan
05.01.2017 updated because of an amendment of ethnic proposal.
View DocumentOther Identifiers
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resveratrol_mpi_01
Identifier Type: -
Identifier Source: org_study_id
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