Molecular and Functional Neurobiology of Physical Exercise

NCT ID: NCT02615756

Last Updated: 2021-03-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

24 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-04-30

Study Completion Date

2018-06-30

Brief Summary

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In this study, we use positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) to study brain mechanisms that contribute to physical exercise-induced reward. We examine whether acute physical exercise releases endogenous opioids in the brain, and whether it modulates brain responses to viewing appetizing foods. Unraveling these mechanism are instrumental from a public health perspective, given the undisputed positive health effects of physical exercise.

Detailed Description

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Conditions

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Physical Exercise Behavior (Liking/Aversion)

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Physical exercise

Group Type EXPERIMENTAL

Exercise

Intervention Type BEHAVIORAL

Interventions

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Exercise

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

1. Native Finnish speaker
2. Age \> 18 years
3. Western Caucasian origin

Exclusion Criteria

1. Age \< 18 or \> 65
2. History or current mental disorder
3. BMI \> 27 kg/m2
4. Use of drugs that influence the central nervous system, including nicotine
5. Poor compliance
6. Any chronic medical defect or injury which hinder or interfere everyday life
7. Eating disorder
8. Current or past excessive use of alcohol or substance abuse
9. Past dose of radiation from medical research such that the annual effective dose will exceed 10 mSv
10. Any other condition that in the opinion of the investigator could create a hazard to the subject safety, endanger the study procedures or interfere with the interpretation of study results
11. Presence of any ferromagnetic objects that would make MR imaging contraindicated
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Academy of Finland

OTHER

Sponsor Role collaborator

Novo Nordisk A/S

INDUSTRY

Sponsor Role collaborator

Juho Vainio Foundation

OTHER

Sponsor Role collaborator

University of Turku

OTHER

Sponsor Role collaborator

Turku University Hospital

OTHER_GOV

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Turku PET Centre

Turku, , Finland

Site Status

Countries

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Finland

Other Identifiers

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19/180/2013

Identifier Type: -

Identifier Source: org_study_id

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