Effects of Disrupting Prolonged Sitting With Different Physical Activity Protocols on Metabolic Risk Factors in Sedentary Adults

NCT ID: NCT02215603

Last Updated: 2016-01-13

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 10 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2014-08-31
• Study Completion Date: 2016-12-31

Brief Summary

Great controversy exists with respect to the optimal or the minimum volume, intensity, and frequency of physical activity capable of attenuating the hazards of prolonged sitting on the metabolic profile. Thus, our study aims to comprehensively investigate the effects of disrupting prolonged sitting with different physical activity protocols on metabolic risk factors in sedentary males.

Ten sedentary males will take part in this randomized cross-over trial consisting of four 27-h conditions. All conditions will be identical except for the physical activity: prolonged sitting intervention (SIT) participants will sit continuously for 9 hours; prolonged sitting+interval standing intervention (STAND), participants will stand for 15 min every 30 minutes (total 270 min) during the 9 hours of sitting; prolonged sitting+moderate-intensity exercise bout (MVPA) participants will perform a 30-min moderate-intensity exercise bout on a treadmill (energy-matched to STAND), after which they will sit for the remaining time; and prolonged sitting+moderate-intensity exercise bout +interval standing intervention (MVPA-STAND), participants will perform a 30-min moderate-intensity exercise bout on a treadmill (energy-matched to STAND), after which they will stand for 15 min every 30 minutes (total 240 min) during the remaining 8 hours of sitting. Blood glucose, insulin, lipids and cytokines will be determined.

The investigators expect that disrupting prolonged sitting with intermittent standing and a moderate-exercise bout will positively affect the metabolic profile of the participants. Furthermore, we will investigate if combined, these strategies will have an additive effect.

Conditions

Prolonged Sitting; Breaking Prolonged Sitting With Physical Activity

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Prolonged sitting

9 h of prolonged sitting

Group Type: NO_INTERVENTION

No interventions assigned to this group

Prolonged sitting + interval standing bouts

Stand bout for 15-min every 30 minutes during the 9 hours of sitting

Group Type: EXPERIMENTAL

Breaking prolonged sitting with physical activity

Intervention Type: BEHAVIORAL

Moderate exercise bout + Prolonged sitting

30-min moderate-intensity exercise bout followed by 8 h of sitting

Group Type: EXPERIMENTAL

Breaking prolonged sitting with physical activity

Intervention Type: BEHAVIORAL

Moderate exercise bout + Prolonged sitting +Standing bouts

30-min moderate-intensity exercise bout and stand bout for 15-min every 30 minutes during the remaining 8 hours of sitting

Group Type: EXPERIMENTAL

Breaking prolonged sitting with physical activity

Intervention Type: BEHAVIORAL

Interventions

Breaking prolonged sitting with physical activity

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• Males,
• age 25-55 y,
• BMI >18 and <35 kg/m2

Exclusion Criteria

• Clinically diagnosed diabetes,
• dyslipidaemia,
• hypertension,
• use of glucose- and/or lipid-lowering medication,
• smoking,
• evidence of thyroid, liver, lung, heart or kidney disease,
• non-sedentary occupation and primary means of commuting to work (i.e., cycling) in the last 4 months,
• VO2max levels above the considered average fitness according to age,
• contraindication to increased levels of physical activity.

• Minimum Eligible Age: 25 Years
• Maximum Eligible Age: 55 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.

OTHER_GOV

Sponsor Role: collaborator

Rigshospitalet, Denmark

OTHER

Sponsor Role: lead

Responsible Party

Anders Rasmussen Rinnov

PhD

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Centre of Inflammation and Metabolism

Copenhagen, , Denmark

Site Status: RECRUITING

Countries

Denmark

Central Contacts

Fabiana Benatti

Role: CONTACT

fabiana.braga.benatti@regionh.dk

+45 35450898

Facility Contacts

Inge Holm

Role: primary

Other Identifiers

ProlongedSitting

Identifier Type: -

Identifier Source: org_study_id