Beta-alanine Supplementation and Its Effects on Performance, Muscle Carnosine Content and Safety in Athletes With Spinal-cord Injury

NCT ID: NCT02604927

Last Updated: 2015-11-16

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 20 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2016-02-29
• Study Completion Date: 2017-09-30

Brief Summary

Paralympians competing in wheelchair sports may experience a very high glycolytic demand (and therefore acidotic environment) in their upper-body muscles, particularly in high-intensity disciplines. Previous studies from our group have shown that upper-body exercise is very sensitive to the ergogenic effects of β-alanine supplementation and to other nutritional supplements capable of increasing buffering capacity. In line with this, have shown that upper-body muscle groups benefit more from artificially induced alkalosis than lower-body muscle groups. Although β-alanine appears to be an interesting and potential ergogenic supplement for paralympians, no study to date has assessed its potential in wheelchair athletes.In this study, we will evaluate the effects of β-alanine supplementation on upper-body performance in wheelchair athletes.

Conditions

Spinal Cord Injuries

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Blinding Strategy: TRIPLE

Study Groups

Placebo

800 mg of dextrose, four times per day, during 28 days.

Group Type: PLACEBO_COMPARATOR

Dextrose

Intervention Type: DIETARY_SUPPLEMENT

Beta-alanine

800 mg of beta-alanine, four times per day, during 28 days.

Group Type: EXPERIMENTAL

Beta-alanine

Intervention Type: DIETARY_SUPPLEMENT

Interventions

Beta-alanine

Intervention Type: DIETARY_SUPPLEMENT

Dextrose

Intervention Type: DIETARY_SUPPLEMENT

Eligibility Criteria

Inclusion Criteria

• Paralympian training for any exercise modality for at least one year;
• A weekly training volume of 6 hours or more;
• Have a spinal cord injury accompanied by loss of motor function in the lower limbs for at least one year;
• Available for carrying out the experimental procedures.

Exclusion Criteria

• Use of creatine or beta-alanine for at least 3 and 6 months before the trial;
• Cardiovascular or respiratory disease;
• Clinical condition that result in malabsorption of nutrients;
• Any other medical condition that prevents the realization of experimental procedures.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 40 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

University of Sao Paulo

OTHER

Sponsor Role: lead

Responsible Party

Bruno Gualano

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

School of Physical Education and Sports, University of Sao Paulo

São Paulo, São Paulo, Brazil

Countries

Brazil

Central Contacts

Guilherme Artioli, PhD

Role: CONTACT

artioli@usp.br

55 11 30913096

Facility Contacts

Guilherme Artioli, PhD

Role: primary

artioli@usp.br

55 11 3091-3096

Other Identifiers

B-Alanine Paraplegic Athletes

Identifier Type: -

Identifier Source: org_study_id