The Reversal of Neuromuscular Adaptation in Human With Spinal Cord Injury II
NCT ID: NCT01968096
Last Updated: 2013-10-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
52 participants
INTERVENTIONAL
2013-08-31
Brief Summary
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Reversal of neuromuscular property for persons with SCI needs to be resolved. Studies using high load electrical stimulations showed a reverse change of muscular properties, such as hypertrophy and reversal of fiber type transformations but failed to show a reversal of spinal circuitry function. Previous studies found that fast continuous passive motion (CPM) altered the H reflex excitability in human. Animal studies found that passive cycling and passive stretching delayed atrophy and influenced the transition of type I and IIa MHC. Theses findings lead to a hypothesis that mechanical stimulation might be able to reverse both spinal circuitry and muscular properties after SCI but it has not been confirmed in human study.
The purpose of this project is to investigate the effect of mechanical stimulation by fast CPM on the reversing adaptation of human paralyzed muscle after SCI.
Detailed Description
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Conditions
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Keywords
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Study Design
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NON_RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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SCI subjects
Stage 1 subjects: pilot study:understand post activation depression with spinal cord injury to avoid the influence of the suprasegmental level.
No interventions assigned to this group
Incomplete SCI subjects
Stage 2 subjects: pilot study:The strength of depression will be evaluated in individuals with and without SCI.
No interventions assigned to this group
Health subjects
Stage 2 subjects: pilot study:The strength of depression will be evaluated in individuals with and without SCI.
No interventions assigned to this group
SCI subjects with high muscle tone (High frequency)
Stage 3 subjects:A rehabilitation program of machine driven passive stretch(High frequency) will be executed .
home-based ankle continuous passive motion machine.
A rehabilitation program of machine driven passive stretch.
SCI subjects with high muscle tone(low frequency)
Stage 3 subjects:A rehabilitation program of machine driven passive stretch(Low frequency) will be executed.
home-based ankle continuous passive motion machine.
A rehabilitation program of machine driven passive stretch.
SCI subjects with high muscle tone
Stage 3 subjects:Control subjects
No interventions assigned to this group
Interventions
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home-based ankle continuous passive motion machine.
A rehabilitation program of machine driven passive stretch.
Eligibility Criteria
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Inclusion Criteria
Stage 2 subjects: Incomplete spinal cord injury subject
* Clinical diagnosis of incomplete spinal cord injury
* ASIA classification:B, C, or D
Stage 3 subjects: Spinal cord injury subjects with high muscle tone
* Clinical diagnosis of spinal cord injury.
* ASIA classification: A, B, C, or D
20 Years
ALL
Yes
Sponsors
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Chang Gung University
OTHER
Responsible Party
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Ya-Ju Chang
Associate Professor
Locations
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Chang Gung University
Taoyuan District, , Taiwan
Countries
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Facility Contacts
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Ya-Ju Chang, PhD
Role: primary
Other Identifiers
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NSC102-2314-B-182-021-MY2
Identifier Type: -
Identifier Source: secondary_id
102-1780C
Identifier Type: -
Identifier Source: org_study_id