Metabolomic Study in Exhaled Breath Condensate of Thoracic Surgical Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

40 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-03-31

Study Completion Date

2018-03-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Acute lung injury (ALI) following thoracic surgery remains a major source of morbidity and mortality after lung resection. One-lung ventilation (OLV) is usually required in thoracic surgery. OLV is also an important predictor of postoperative ALI. Recent laboratory findings suggested that tissue hypoxemia and ischemia / reperfusion injury of the collapsed lungs during OLV is the major cause of lung injury. Exhaled Breath Condensate (EBC), which is the exhalate from breath typically collected by cooling device, contains most molecules found in the airway. Metabolomics refers to systematic and scientific study of chemical processes involving metabolites. This study will collect EBC for metabolomic analysis and aim to elucidate the biochemical reactions during one-lung ventilation and pathological mechanisms of acute lung injury following thoracic surgery.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Comparative Analysis of the Lung Inflammatory Response After Thoracic Surgery With Single or Double Lung Ventilation: a Randomized, Pilot, Trial

NCT05982639

Thoracic Diseases Surgery

COMPLETED PHASE2

Hemodynamic Changes During One Lung Ventilation in Non-intubated Vedio-assisted Thoracoscopic Operations

NCT02123173

Lung Neoplasms

COMPLETED

Lung Transplantation in Respiratory Failure Patients

NCT00854165

Respiratory Failure

UNKNOWN

Effects of Oxygen on Lung Tissue During Anesthesia

NCT00715338

Lung Injury, Acute

TERMINATED

Effects of Recruitment Maneuvers in Early Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS) Patients

NCT01114009

Acute Respiratory Distress Syndrome Lung Injury, Acute

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Acute lung injury (ALI) following thoracic surgery remains a major source of morbidity and mortality after lung resection. Despite the advancement in both the surgical techniques and the perioperative management, the incidence of postoperative ALI remains remarkable. Risk factors for postoperative lung injury are evident, including preoperative pulmonary function, type of surgical procedure, intraoperative fluid management, one-lung ventilation, and ventilator settings. One-lung ventilation (OLV) is usually required in thoracic surgery. OLV is also an important predictor of postoperative ALI. Recent laboratory findings suggested that tissue hypoxemia and ischemia / reperfusion injury of the collapsed lungs during OLV is the major cause of lung injury. Exhaled Breath Condensate (EBC), which is the exhalate from breath typically collected by cooling device, contains most molecules found in the airway. EBC analysis has potential applications in lung disease, such as severity of airway inflammation in asthmatic patients. Collecting EBC is simple and non-invasive, in contrast to bronchoscopy for lung biopsy or bronchoalveolar lavage. Metabolomics refers to systematic and scientific study of chemical processes involving metabolites. This study will collect EBC from thoracic surgical patients before, during, and after OLV. The investigators will perform metabolomic analysis and aim to elucidate the biochemical reactions during one-lung ventilation and pathological mechanisms of acute lung injury following thoracic surgery.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Acute Pulmonary Insufficiency Following Thoracic Surgery Ventilator-associated Lung Injury

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Thoracic Surgery with Lung Resection

General anesthesia and lung separation Thoracic Surgery with Lung Resection, such as lobectomy, segmentectomy

Thoracic Surgery with Lung Resection

Intervention Type PROCEDURE

General anesthesia and lung separation Thoracic surgery with lung resection, such as lobectomy, segmentectomy

Thoracic Surgery without Lung Resection

General anesthesia and lung separation Thoracic Surgery without Lung Resection, such as esophageal surgery, mediastinal surgery

Thoracic Surgery without Lung Resection

Intervention Type PROCEDURE

General anesthesia and lung separation Thoracic surgery without lung resection, such as esophageal surgery, mediastinal surgery

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Thoracic Surgery with Lung Resection

General anesthesia and lung separation Thoracic surgery with lung resection, such as lobectomy, segmentectomy

Intervention Type PROCEDURE

Thoracic Surgery without Lung Resection

General anesthesia and lung separation Thoracic surgery without lung resection, such as esophageal surgery, mediastinal surgery

Intervention Type PROCEDURE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Thoracic surgical patients requiring lung isolation
* Pulmonary resection: lobectomy, segmentectomy
* Esophageal surgery and no pulmonary resection
* Mediastinal surgery and no pulmonary resection