Prevention of Postoperative Acute Kidney Injury

NCT ID: NCT02583945

Last Updated: 2018-06-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Study Start Date

2015-10-31

Study Completion Date

2017-10-31

Brief Summary

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Postoperative acute kidney injury (AKI) refers to increased mortality and morbidity in patients after non-cardiac surgery. The Kidney Disease Improving Global Outcomes (KDIGO)-guidelines recommend a bundle of procedures to prevent the occurrence of AKI: A protocol for the improvement of the hemodynamic situation and a standardized proceeding in hemodynamic monitoring, consequent avoidance of nephrotoxic substances, regular measurement of creatinine and urine output, as well as normoglycemia. The primary goal is to determine if the consequent application of the KDIGO-bundle leads to a prevention of the occurrence of AKI in patients at risk after non-cardiac surgery.

Detailed Description

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All patients included in the study will be treated with the KDIGO-bundle (hemodynamic stabilization, avoidance of nephrotoxic substances, normoglycemia and measurement of creatinine in serum and urine output). 12 h, 24h as well as on day 2, 3, 5 and 10 after admission on ICU the occurence of AKI (according to KDIGO) will be assessed.

Conditions

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Acute Kidney Injury

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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kidney treatment bundle (KDIGO)

Consequent postoperative application of a kidney treatment bundle: Protocol based hemodynamic optimization and monitoring, regular screening of creatinine in serum and of urine output, no use of potential nephrotoxic medication and normoglycemia.

Group Type EXPERIMENTAL

kidney treatment bundle (KDIGO)

Intervention Type PROCEDURE

Application of the measures of the kidney treatment bundle.

Interventions

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kidney treatment bundle (KDIGO)

Application of the measures of the kidney treatment bundle.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Age \> 65 years
* chronic kidney disease
* diabetes mellitus, chronic heart, lung or liver disease
* hemodynamic instability (intra and/or post-operative)
* trauma, burn injury, major surgery, usage of x-ray contrast and sepsis.

Exclusion Criteria

* Age \< 18 years
* pregnancy
* kidney graft recipient
* chronic renal disease with or without renal replacement therapy and cardiac surgery.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Wuerzburg University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Prof. Dr. Christian Wunder

Vice chair and leading senior physician

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Christian Wunder, MD

Role: PRINCIPAL_INVESTIGATOR

University of Wuerzburg

Locations

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University Hospital Wuerzburg, Dep. of Anesthesiology

Würzburg, , Germany

Site Status

Countries

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Germany

Other Identifiers

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022015

Identifier Type: -

Identifier Source: org_study_id

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