ABCB5 as a Prognostic Marker in Survival of Cultivated Limbal Stem Cell Transplantation
NCT ID: NCT02579993
Last Updated: 2018-03-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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TERMINATED
NA
10 participants
INTERVENTIONAL
2015-03-31
2018-03-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
TREATMENT
NONE
Study Groups
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Stem Cell Transplantation
Cultivated Limbal Stem Cell Transplantation
Pannus and conjunctival dissection
A complete conjunctival peritomy is performed and the fibrovascular pannus and conjunctiva invading the cornea is dissected from the cornea and limbus.
Human cultivated limbal stem cell transplantation
The amniotic membrane graft cultured with the human limbal stem cell transplantation is placed in the limbic and corneal surface and fixed with fibrin glue. The amniotic membrane is placed with the stroma in contact with the graft and it is sutured.
Interventions
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Pannus and conjunctival dissection
A complete conjunctival peritomy is performed and the fibrovascular pannus and conjunctiva invading the cornea is dissected from the cornea and limbus.
Human cultivated limbal stem cell transplantation
The amniotic membrane graft cultured with the human limbal stem cell transplantation is placed in the limbic and corneal surface and fixed with fibrin glue. The amniotic membrane is placed with the stroma in contact with the graft and it is sutured.
Eligibility Criteria
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Inclusion Criteria
2. Corneal impression cytology positive for goblet cells.
3. Ocular ultrasound results within normal parameters.
4. Agree to participate in the study and sign the informed consent.
Exclusion Criteria
16 Years
ALL
No
Sponsors
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National Council of Science and Technology, Mexico
OTHER
Instituto de Oftalmología Fundación Conde de Valenciana
OTHER
Responsible Party
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Principal Investigators
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Yonathan Garfias, MD, PhD
Role: STUDY_DIRECTOR
Instituto de Oftalmologia Conde de Valenciana
Locations
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Instituto de Oftalmologia Conde de Valenciana
Mexico City, , Mexico
Countries
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References
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Serna-Ojeda JC, Garcia-Mejia M, Graue-Hernandez EO, Navas A, Garfias Y. Short-Term Results Analysis in the Allogenic Transplantation of Limbal Stem Cells Expanded on Amniotic Membrane in Patients with Bilateral Limbal Stem Cell Deficiency. J Ocul Pharmacol Ther. 2020 May;36(4):238-246. doi: 10.1089/jop.2019.0147. Epub 2020 Feb 20.
Other Identifiers
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CI-051-2014
Identifier Type: -
Identifier Source: org_study_id
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