The Changes Within the Cells of the Drainage System of the Eye in Patients With Glaucoma
NCT ID: NCT02524431
Last Updated: 2016-11-21
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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WITHDRAWN
NA
INTERVENTIONAL
2014-11-30
2016-01-31
Brief Summary
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Detailed Description
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Conditions
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Keywords
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Study Design
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NON_RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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Glaucoma subjects
During glaucoma surgery, collection of trabecular meshwork tissue during surgery that is not needed is cut away from the surgical site. The physician will keep this tissue for analysis by the researchers at Wills Eye Hospital and Thomas Jefferson University Center for Translational Medicine.
Collection of trabecular meshwork tissue during surgery
Tissue is collected during surgery at Wills Eye and then processed at thomas jefferson to identify the trabecular meshwork using light microscope. The ocular tissue will be fixed and the mitochondrial cross sections at the longest extent will be measured under electron microscopy (EM) in order to identify the mitochondrial dynamics. Quantitative Polymerase Chain Reaction (qPCR) will be done to identify proteins responsible for mitochondrial fusion.
Control cadaver eyes
control cadaver eye are ordered and the collection of trabecular meshwork tissue during surgery and is processed at Thomas Jefferson University
Collection of trabecular meshwork tissue during surgery
Tissue is collected during surgery at Wills Eye and then processed at thomas jefferson to identify the trabecular meshwork using light microscope. The ocular tissue will be fixed and the mitochondrial cross sections at the longest extent will be measured under electron microscopy (EM) in order to identify the mitochondrial dynamics. Quantitative Polymerase Chain Reaction (qPCR) will be done to identify proteins responsible for mitochondrial fusion.
Interventions
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Collection of trabecular meshwork tissue during surgery
Tissue is collected during surgery at Wills Eye and then processed at thomas jefferson to identify the trabecular meshwork using light microscope. The ocular tissue will be fixed and the mitochondrial cross sections at the longest extent will be measured under electron microscopy (EM) in order to identify the mitochondrial dynamics. Quantitative Polymerase Chain Reaction (qPCR) will be done to identify proteins responsible for mitochondrial fusion.
Eligibility Criteria
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Inclusion Criteria
* Moderate to advanced stage of the disease
* DDLS stages 5 through 10 with visual field loss
* Age between 21 and 80 years
* Planned trabeculectomy with or without concomitant cataract surgery
Exclusion Criteria
* Any other type of glaucoma other than POAG
* Patients who had undergone selective laser trabeculoplasty (SLT) or argon laser trabeculoplasty (ALT)
* Patients with history of ocular trauma
* Patients with previous eye surgery will be excluded both from the study and the control groups
21 Years
80 Years
ALL
No
Sponsors
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Thomas Jefferson University
OTHER
Wills Eye
OTHER
Responsible Party
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George L. Spaeth MD
Principal investigator
Principal Investigators
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George Spaeth, MD
Role: PRINCIPAL_INVESTIGATOR
Wills Eye Hospital
Locations
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Wills Eye Hospital
Philadelphia, Pennsylvania, United States
Countries
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Other Identifiers
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14-430E
Identifier Type: -
Identifier Source: org_study_id