Impact of Boostrix™ Maternal Vaccination on Morbidity and Mortality of Pertussis Disease in Infants ≤6 Weeks of Age, in Bogota, Colombia.

NCT ID: NCT02569879

Last Updated: 2024-02-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

1 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-10-01

Study Completion Date

2018-04-14

Brief Summary

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This study is being conducted to assess impact of maternal immunisation against pertussis in infants ≤12 months of age before and after introduction of pertussis maternal immunisation in Bogota, Colombia from January 2005-December 2014.

Detailed Description

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An observational, retrospective, ecological database study which involves systematic screening of the national databases of Bogota, to study pertussis related morbidity and mortality in infants ≤ 12 months of age before and after introduction of pertussis maternal immunisation in Bogota, Colombia from January 2005-December 2014.

Conditions

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Diphtheria Acellular Pertussis Tetanus Aspergillosis, Allergic Bronchopulmonary Diphtheria-Tetanus-acellular Pertussis Vaccines

Study Design

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Observational Model Type

ECOLOGIC_OR_COMMUNITY

Study Time Perspective

RETROSPECTIVE

Study Groups

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Infants Group

* All infants ≤12 months of age in Bogota, reported with pertussis disease in the national databases of Bogota, between January 2005 and December 2014.
* All infants ≤12 months of age in Bogota, deceased between January 2005 and December 2014 due to pertussis disease (primary diagnosis), based on death certificate information.
* All infants ≤12 months of age in Bogota, with ALRTI, between January 2005 and December 2014.
* All infants ≤12 months who have received primary pertussis vaccination in Bogota, between January 2005 and December 2014.

Pertussis maternal immunization

Intervention Type OTHER

Retrospective time trend analysis before and after pertussis maternal immunization in Bogota, Colombia.

Pregnant women Group

• Pregnant women will be included in the study to assess the vaccination coverage of Boostrix from March 2013 to December 2014

Pertussis maternal immunization

Intervention Type OTHER

Retrospective time trend analysis before and after pertussis maternal immunization in Bogota, Colombia.

Interventions

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Pertussis maternal immunization

Retrospective time trend analysis before and after pertussis maternal immunization in Bogota, Colombia.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

• Not applicable as since this retrospective database study will include all the available aggregated data of pertussis cases, pertussis related hospitalisations and deaths, ALRTI cases, primary pertussis vaccination coverage and Boostrix vaccination coverage.

Exclusion Criteria

• Not applicable as since this retrospective database study will include all the available aggregated data of pertussis cases, pertussis related hospitalisations and deaths, ALRTI cases, primary pertussis vaccination coverage and Boostrix vaccination coverage.
Minimum Eligible Age

0 Days

Maximum Eligible Age

12 Months

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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GlaxoSmithKline

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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GSK Clinical Trials

Role: STUDY_DIRECTOR

GlaxoSmithKline

Locations

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GSK Investigational Site

Bogotá, , Colombia

Site Status

Countries

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Colombia

References

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Carrasquilla G, Porras A, Martinez S, DeAntonio R, Devadiga R, Caceres DC, Juliao P. Incidence and mortality of pertussis disease in infants <12 months of age following introduction of pertussis maternal universal mass vaccination in Bogota, Colombia. Vaccine. 2020 Oct 27;38(46):7384-7392. doi: 10.1016/j.vaccine.2020.07.046. Epub 2020 Oct 2.

Reference Type BACKGROUND
PMID: 33012607 (View on PubMed)

Other Identifiers

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201521

Identifier Type: -

Identifier Source: org_study_id

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