Serum Lactate Trend in Liver Resection

NCT ID: NCT02565329

Last Updated: 2015-10-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

133 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-01-31

Study Completion Date

2015-02-28

Brief Summary

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The study aimed to evaluate the correlation between the serum lactate concentration ed cumulative Pringle time after liver resection. In addition, the correlation between lactate clearance and clamping time was investigated.

Detailed Description

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During liver resection high serum lactate (sLac) concentration can be related to several clinical factors: impairment in lactate metabolism (i.e. extraction and utilization by the liver) or overproduction by splanchnic tissues; restrictive fluid regimen in order to limit the intraoperative back-flow bleeding; ischemia-reperfusion syndrome. However, the Pringle maneuver (temporary clamping of the hepatic hilum) seems having a sensible effect in inducing a significant increase in sLac levels during liver resection, particularly in the event of compromised liver function such as in cirrhosis.

Although the peak of sLac concentration may correlate with outcome, the lactate clearance (cLac) seems to be a better predictor. To date, this relationship has been mainly demonstrated in severe sepsis and shock septic. However, the effective correlation between the cumulative clamping time and cLac has not been clearly investigated. The correlation between cumulative hepatic ischemic time and sLac trend in the perioperative period after liver resection with intermittent PM was investigated.

Conditions

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Lactase Persistence

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Patients scheduled for liver resection for hepatic tumors

Exclusion Criteria

* Patients who received blood transfusion or affected by chronic renal failure were excluded
Minimum Eligible Age

34 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Milan

OTHER

Sponsor Role lead

Responsible Party

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Prof. Guido Torzilli

Prof Guido Torzilli, MD, PhD, FACS

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Guido Guido, Guido

Role: PRINCIPAL_INVESTIGATOR

Humanitas Research Hospital, Humanitas University, via Manzoni 56, 20089 Milan

Locations

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Department of Hepatobiliary and General Surgery, Humanitas Research Hospital, University of Milan

Rozzano, Milan, Italy

Site Status

Countries

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Italy

Other Identifiers

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LacClearance

Identifier Type: -

Identifier Source: org_study_id

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