Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
35 participants
INTERVENTIONAL
2013-01-31
2015-09-30
Brief Summary
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Detailed Description
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The collected data of these patients will be retrospectively matched with data obtained from 35 historical controls who received conventional treatment with endotracheal intubation. The study will retrospectively compare intubation rate, acid base homeostasis, norepinephrine requirements (in the patients who due to clinical conditions were under norepinephrine before starting extracorporeal Co2 removal ) and coagulation parameters.
Conditions
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Study Design
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NA
SINGLE_GROUP
TREATMENT
NONE
Study Groups
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hypercapnic patients
patients with acute hypercapnic respiratory failure due to exacerbation of chronic obstructive pulmonary disease, refused endotracheal intubation after failing NIV and were treated withLow flow etracorporeal CO2 removal
LOW FLOW EXTRACORPOREAL CO2 REMOVAL, PROLUNG ESTOR
Interventions
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LOW FLOW EXTRACORPOREAL CO2 REMOVAL, PROLUNG ESTOR
Eligibility Criteria
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Inclusion Criteria
* failure of non invasive ventilation
* expression of a clear intention not to be intubated
Exclusion Criteria
* contraindications to anticoagulation
18 Years
ALL
No
Sponsors
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University of Roma La Sapienza
OTHER
Responsible Party
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Andrea Morelli
MD. Associate professor
Principal Investigators
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Andrea Morelli, MD
Role: PRINCIPAL_INVESTIGATOR
University of Roma La Sapienza
Locations
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Dept of Anesthesiology and Intensive Care
Rome, , Italy
Countries
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References
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Burki NK, Mani RK, Herth FJF, Schmidt W, Teschler H, Bonin F, Becker H, Randerath WJ, Stieglitz S, Hagmeyer L, Priegnitz C, Pfeifer M, Blaas SH, Putensen C, Theuerkauf N, Quintel M, Moerer O. A novel extracorporeal CO(2) removal system: results of a pilot study of hypercapnic respiratory failure in patients with COPD. Chest. 2013 Mar;143(3):678-686. doi: 10.1378/chest.12-0228.
Del Sorbo L, Pisani L, Filippini C, Fanelli V, Fasano L, Terragni P, Dell'Amore A, Urbino R, Mascia L, Evangelista A, Antro C, D'Amato R, Sucre MJ, Simonetti U, Persico P, Nava S, Ranieri VM. Extracorporeal Co2 removal in hypercapnic patients at risk of noninvasive ventilation failure: a matched cohort study with historical control. Crit Care Med. 2015 Jan;43(1):120-7. doi: 10.1097/CCM.0000000000000607.
Other Identifiers
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3785
Identifier Type: -
Identifier Source: org_study_id
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