Subfoveal Choroidal Thickness in Thai Population

NCT ID: NCT02551601

Last Updated: 2019-08-14

Basic Information

• Recruitment Status: TERMINATED
• Total Enrollment: 150 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2015-08-31
• Study Completion Date: 2018-08-31

Brief Summary

The purpose of this study was to determine the subfoveal choroidal thickness in normal Thai eyes and study the associations with gender, age, refractive error and axial length using spectral-domain optical coherence tomography with enhanced depth imaging technique.

Detailed Description

Alteration of choroidal blood supply causes changes in choroidal thickness and results in choroidal abnormalities. These are usually associated with retinal diseases and leading to severe visual dysfunction. Choroidal thickness is therefore helpful in diagnosis and treatment for many chorioretinal conditions. With the advent of spectral domain optical coherence tomography and enhanced depth imaging technique, choroidal thickness has been investigated widely in normal eyes and various chorioretinal diseases including central serous chorioretinopathy (CSC), age-related macular degeneration (AMD), highly myopia and Vogt Koyanagi-Harada disease. Similar to retinal thickness, a normal baseline choroidal thickness might be used for interpretation. This value might be affected by several variables including age, gender and ethnicity. Although there were previous studies on subfoveal choroidal thickness in normal eyes from many countries, there has been no such study in Thailand. The purpose of this study was to determine the subfoveal choroidal thickness in normal Thai eyes and study the associations with gender, age, refractive error and axial length using SD-OCT and EDI technique.

Conditions

Healthy

Study Design

• Observational Model Type: CASE_ONLY
• Study Time Perspective: PROSPECTIVE

Study Groups

Healthy volunteers

to measure the subfoveal choroidal thickness in healthy volunteers

measure subfoveal choroidal thickness

Intervention Type: OTHER

measure subfoveal choroidal thickness using optical coherence tomography

Interventions

measure subfoveal choroidal thickness

measure subfoveal choroidal thickness using optical coherence tomography

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Age 18 years or above
• Healthy subjects
• No ocular diseases
• Written informed consent form

Exclusion Criteria

• patients with systemic diseases that may affect retinal or choroidal thickness including diabetes
• patients with history of refractive surgeries, intraocular surgeries or retinal laser treatments
• patients with history of macular, retinal, or optic nerve abnormalities

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Khon Kaen University

OTHER

Sponsor Role: lead

Responsible Party

Yosanan Yospaiboon

Department of Ophthalmology, Faculty of Medicine, Khon Kaen University

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Yosanan Yospaiboon, MD

Role: PRINCIPAL_INVESTIGATOR

Department of Ophthalmology, Khon Kaen University

Locations

Eye outpatients department, Srinagarind Hospital, Khon Kaen University

Khon Kaen, , Thailand

Countries

Thailand

Other Identifiers

HE561056

Identifier Type: -

Identifier Source: org_study_id