A Registry of Participants With Prostate Cancer in Asia

NCT ID: NCT02546908

Last Updated: 2020-09-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

3644 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-09-09

Study Completion Date

2020-09-01

Brief Summary

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The purpose of this study is to document prostate cancer (PC) management including diagnosis, prognosis, treatment, and care in real-world practice.

Detailed Description

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This is a multicenter (when more than one hospital or medical school team work on a medical research study), prospective (observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group), longitudinal, observational registry (clinical study in which participants may receive diagnostic, therapeutic, or other types of interventions, but the investigator does not assign participants to specific interventions \[as in an interventional study\])of PC participants. The following 3 participant cohorts will be enrolled: high-risk localized PC, non-metastatic biochemically recurrent PC, and metastatic PC. This is an observational study and treatment decisions and clinical management of participants will follow routine clinical practice. Medical care given to participants will not be influenced by participation in the study. Enrolled participants will be prospectively followed throughout their course of treatment, during which data on PC treatment, clinical progression, and outcomes (including death) will be collected. At the end of registry medical resource utilization (MRU) will also be collected. The maximum observational period will be 5 years. Safety will be monitored throughout the study for participants being treated with JNJ products.

Conditions

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Prostatic Neoplasms

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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High-risk localized Prostate Cancer (PC)

No intervention will be administered in this study. Participants with High-risk localized PC will be enrolled. High-risk localized PC involves clinical T stage greater than or equal to (\>=) cT3a and one of the following high risk features: Gleason score 8-10 or prostate specific antigen (PSA) level above 20 nanogram per milliliter (ng/mL).

No Intervention

Intervention Type OTHER

This is an observational study. No study medication is provided will be provided as part of participation. Participants disease status, overall survival (OS), PFS, MFS, SRE-free survival, and time to castration (TTC) will be analyzed according to treatments prescribed while enrolled in the registry. All treatment decisions will be made at the discretion of the investigator or treating physician.

Non-metastatic Biochemically Recurrent PC

No intervention will be administered in this study. Participants with Non-metastatic biochemically recurrent PC will be enrolled. A non-metastatic biochemically recurrent PC involves a confirmed PSA value of \>0.2 ng/mL following prostatectomy (European Association of Urology (EAU) guidelines), a PSA value of 2 ng/mL or more above the nadir following radiation therapy (American Society for Radiation Oncology (ASTRO) guidelines).

No Intervention

Intervention Type OTHER

This is an observational study. No study medication is provided will be provided as part of participation. Participants disease status, overall survival (OS), PFS, MFS, SRE-free survival, and time to castration (TTC) will be analyzed according to treatments prescribed while enrolled in the registry. All treatment decisions will be made at the discretion of the investigator or treating physician.

Metastatic PC

No intervention will be administered in this study. Participants with Metastatic PC will be enrolled.

No Intervention

Intervention Type OTHER

This is an observational study. No study medication is provided will be provided as part of participation. Participants disease status, overall survival (OS), PFS, MFS, SRE-free survival, and time to castration (TTC) will be analyzed according to treatments prescribed while enrolled in the registry. All treatment decisions will be made at the discretion of the investigator or treating physician.

Interventions

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No Intervention

This is an observational study. No study medication is provided will be provided as part of participation. Participants disease status, overall survival (OS), PFS, MFS, SRE-free survival, and time to castration (TTC) will be analyzed according to treatments prescribed while enrolled in the registry. All treatment decisions will be made at the discretion of the investigator or treating physician.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Male aged 21 years or older
* Documented diagnosis of PC with either: High-risk localized PC; Non-metastatic, biochemically recurrent PC; Metastatic PC
* Signed participation agreement/Informed Consent Form (ICF) by the patient or a legally acceptable representative
* Agree to be followed-up for PC per routine clinical care
Minimum Eligible Age

21 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Janssen Research & Development, LLC

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Janssen Research & Development, LLC Clinical Trial

Role: STUDY_DIRECTOR

Janssen Research & Development, LLC

Locations

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Beijing, , China

Site Status

Guangzhou, , China

Site Status

Hangzhou, , China

Site Status

Shanghai, , China

Site Status

Shenyang, , China

Site Status

Sichuan, , China

Site Status

Suzhou, , China

Site Status

Wuhan, , China

Site Status

Bangalore, , India

Site Status

Delhi, , India

Site Status

Mumbai, , India

Site Status

New Delhi, , India

Site Status

Chiba, , Japan

Site Status

Hirosaki, , Japan

Site Status

Ikoma, , Japan

Site Status

Kobe, , Japan

Site Status

Koshigaya, , Japan

Site Status

Matsuyama, , Japan

Site Status

Ōsaka-sayama, , Japan

Site Status

Suita, , Japan

Site Status

Kuala Lumpur, , Malaysia

Site Status

Kuching, , Malaysia

Site Status

Pulau Pinang, , Malaysia

Site Status

Singapore, , Singapore

Site Status

Seoul, , South Korea

Site Status

Kaohsiung City, , Taiwan

Site Status

Tainan City, , Taiwan

Site Status

Taipei, , Taiwan

Site Status

Bangkok, , Thailand

Site Status

Chiang Mai, , Thailand

Site Status

Songkhla, , Thailand

Site Status

Countries

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China India Japan Malaysia Singapore South Korea Taiwan Thailand

References

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Ye D, Kanesvaran R, Chiong E, Lojanapiwat B, Pu YS, Rawal SK, Aik OT, Zeng H, Chung BH, Ashani MYN, Ohyama C, Kim CS, Hu Z, Tsai YS, Razack AHA, Singh A, Liu Y, Uemura H. UFO registry: final analysis of baseline data from patients with advanced prostate cancer in Asia. Ther Adv Med Oncol. 2024 Nov 23;16:17588359241293393. doi: 10.1177/17588359241293393. eCollection 2024.

Reference Type DERIVED
PMID: 39583953 (View on PubMed)

Uemura H, Ye D, Kanesvaran R, Chiong E, Lojanapiwat B, Pu YS, Rawal SK, Abdul Razack AH, Zeng H, Chung BH, Md Yusoff NA, Ohyama C, Kim CS, Leewansangtong S, Tsai YS, Liu Y, Liu W, van Kooten Losio M, Asinas-Tan M. United in Fight against prOstate cancer (UFO) registry: first results from a large, multi-centre, prospective, longitudinal cohort study of advanced prostate cancer in Asia. BJU Int. 2020 Apr;125(4):541-552. doi: 10.1111/bju.14980. Epub 2020 Jan 30.

Reference Type DERIVED
PMID: 31868997 (View on PubMed)

Liu Y, Uemura H, Ye D, Lee JY, Chiong E, Pu YS, Razack AHA, Pripatnanont C, Rawal S, Low GKM, Qiu H, Chow WH, Van Kooten Losio M. Prostate cancer in Asia: design of a patient registry to inform real-world treatments, outcomes, and quality of life. Prostate Int. 2019 Sep;7(3):108-113. doi: 10.1016/j.prnil.2018.12.001. Epub 2018 Dec 24.

Reference Type DERIVED
PMID: 31485435 (View on PubMed)

Other Identifiers

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NOPRODPCR4001

Identifier Type: OTHER

Identifier Source: secondary_id

CR107351

Identifier Type: -

Identifier Source: org_study_id

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