The Research of Standard Diagnosis and Treatment for HSPN With Mild Proteinuria in Children
NCT ID: NCT02532790
Last Updated: 2020-02-26
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
PHASE2
100 participants
INTERVENTIONAL
2015-08-31
2020-07-31
Brief Summary
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Detailed Description
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The patients who are proved to get HSPN by renal biopsy will be randomized to receive either prednisone p.o. or angiotensin-converting enzyme inhibitor(ACEI) p.o. We will follow up them for about 2.5 years and compare the efficacy and safety of both measures by monitoring several indexes.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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group 1
Prednisone Drug : prednisone 1.5mg/kg/d for 4-6 weeks, then 1.5mg/kg/d qod for 4 weeks, reduce 5mg every 2-4 weeks If the proteinuria decreases by less than 50% after treating for two months, this candidate reaches the ending point.
Prednisone
1.5mg/kg/d
group 2
Angiotension converting enzyme inhibitors(ACEI) Drug: lotensin 0.2-0.3mg/kg/d (the maximum dose is 20mg)
ACEI
0.2-0.3mg/kg/d
Interventions
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Prednisone
1.5mg/kg/d
ACEI
0.2-0.3mg/kg/d
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Proteinuria \< 25 mg/kg/d
Exclusion Criteria
* Proteinuria≥25 mg/kg/d
2 Years
16 Years
ALL
No
Sponsors
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Nanjing Children's Hospital
OTHER
Responsible Party
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Aihua Zhang
Hospital vice president
Principal Investigators
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Aihua Zhang, M.D.
Role: STUDY_CHAIR
Department of Nephrology, Nanjing children's hospital
Locations
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Nanjing Children's Hospital
Nanjing, Jiangsu, China
Countries
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Central Contacts
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Facility Contacts
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References
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Hahn D, Hodson EM, Craig JC. Interventions for preventing and treating kidney disease in IgA vasculitis. Cochrane Database Syst Rev. 2023 Feb 28;2(2):CD005128. doi: 10.1002/14651858.CD005128.pub4.
Other Identifiers
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AiZhang
Identifier Type: -
Identifier Source: org_study_id
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