The Effectiveness of Enough Steroids as Inducement Therapy in Minimal Change Disease-like IgA Nephropathy
NCT ID: NCT01451710
Last Updated: 2012-07-10
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
30 participants
INTERVENTIONAL
2011-03-31
2012-05-31
Brief Summary
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Detailed Description
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2. The safety of enough steroids as inducement therapy in adult minimal change disease-like IgA nephropathy patients
Conditions
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Keywords
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Study Design
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NA
SINGLE_GROUP
TREATMENT
NONE
Study Groups
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Prednisone or Prednisolone
Prednisone or Prednisolone
daily single dose of 1mg/kg (maximum 80mg) or alternate day single dose of 2mg/kg (maximum 120mg),maintained for a minimum period of 6 weeks and maximum period of 12 weeks. After achieving complete remission., corticosteroids should be tapered slowly, 10mg every two weeks tapered to reach 0.15mg/kg/d, then 2.5mg every two to four weeks tapered to reach the minimum dosage 10mg/ alternate day
Interventions
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Prednisone or Prednisolone
daily single dose of 1mg/kg (maximum 80mg) or alternate day single dose of 2mg/kg (maximum 120mg),maintained for a minimum period of 6 weeks and maximum period of 12 weeks. After achieving complete remission., corticosteroids should be tapered slowly, 10mg every two weeks tapered to reach 0.15mg/kg/d, then 2.5mg every two to four weeks tapered to reach the minimum dosage 10mg/ alternate day
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Renal biopsy was used to diagnose IgA nephropathy
* Patients with 24h proteinuria 3.5g and serum albumin concentration lower than 30g/L
Exclusion Criteria
* urine RBC \> 1 million/ml
* Patients who have received treatment of enough steroids for more than 12 weeks
* patients with secondary IgA
* Patients who have impaired liver function,with ALT/GPT or AST/GOT twice more than the normal upper limit or who have active hepatitis
* Patients with 2 type diabetes or obesity, whose BMI is more than 28kg/m2
18 Years
65 Years
ALL
No
Sponsors
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Nanjing University School of Medicine
OTHER
Responsible Party
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Zhi-Hong Liu, M.D.
Research Institute of Nephrology, Jinling Hospital, Nanjing University School of Medicine
Principal Investigators
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Zhihong Liu, MD
Role: STUDY_DIRECTOR
Research Institute of Nephrology, Jinling Hospital, Nanjing University School of Medicine
Locations
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Research Institute of Nephrology, Jinling Hospital, Nanjing University School of Medicine
Nanjing, Jiangsu, China
Countries
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References
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Wang J, Juan C, Huang Q, Zeng C, Liu Z. Corticosteroid therapy in IgA nephropathy with minimal change-like lesions: a single-centre cohort study. Nephrol Dial Transplant. 2013 Sep;28(9):2339-45. doi: 10.1093/ndt/gft211. Epub 2013 Jun 19.
Other Identifiers
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NJCT-1102
Identifier Type: -
Identifier Source: org_study_id