Renal Arteries Dysplastic Aneurysms: Anatomopathological and Genetic Study
NCT ID: NCT02528149
Last Updated: 2015-08-19
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
34 participants
OBSERVATIONAL
2013-09-30
2014-12-31
Brief Summary
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This is a rare blood disease, occurring in children and young adults. In this young population with long life expectancy, these aneurysmal lesion are associated with 10% risk of rupture. To date, no data have shown in the literature that FMD is link to genetic causes, or if there is specific histopathologic lesions for non-atherosclerotic renal artery aneurysms.
To answer these questions, Cardiovascular Surgery Unit of the University Hospital of Saint-Etienne, French national reference center for renal artery surgery, in association with the Reference Center for Rare Vascular Disease in Paris, designed the first study for pathological and genetic characteristics of dysplastic renal artery aneurysms in young patients.
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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patients with renal aneurysm
Patient with one or more renal artery aneurysm (RAA) operated and with tissue; adjacent part and aneurysm; cryopreserved. Blood sample performed at day 1.
tissue of adjacent part and aneurysm of renal aneurysm
the samples are collected during surgery of renal artery aneurysms. Th tissue is cryopreserved in liquid nitrogen before analysis
blood sample
Interventions
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tissue of adjacent part and aneurysm of renal aneurysm
the samples are collected during surgery of renal artery aneurysms. Th tissue is cryopreserved in liquid nitrogen before analysis
blood sample
Eligibility Criteria
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Inclusion Criteria
* Patient (or parent/person having parental authority) Affiliate or entitled to a social security scheme.
* Signature of patient consent (or parents or holder of parental authority)
Exclusion Criteria
* Patient refusing to participate in the study and / or genetic analysis or, for juvenile patients, parents or holder of parental authority refusing the minor patient to be involved in the study and / or genetic analysis.
* Patient with FMD whose samples in the tissue collection did not concern aneurysm.
15 Years
ALL
No
Sponsors
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Centre Hospitalier Universitaire de Saint Etienne
OTHER
Responsible Party
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Principal Investigators
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Xavier Barral, PhD
Role: PRINCIPAL_INVESTIGATOR
CHU SAINT-ETIENNE
Locations
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CH Henri Mondor
Aurillac, , France
CH Louis Pasteur
Bagnols-sur-Cèze, , France
CHU Saint-Jacques
Besançon, , France
Groupe Hospitalier Pellegrin
Bordeaux, , France
Clinique Saint-Germain
Brive-la-Gaillarde, , France
Centre Hospitalier A. Gayraud
Carcassonne, , France
CH W. Morey
Chalon-sur-Saône, , France
Hôpital Gabriel Montpied
Clermont-Ferrand, , France
CH Emile Roux
Le Puy-en-Velay, , France
Hôpital Jeanne de Flandre
Lille, , France
Hôpital de la mère et de l'enfant
Limoges, , France
Hôpital Robert Schuman
Metz, , France
Hôpital Lapeyronie
Montpellier, , France
CHU Nantes
Nantes, , France
CH Niort
Niort, , France
Hôpital Européen Georges Pompidou
Paris, , France
CHRU Tours
Tours, , France
Countries
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Other Identifiers
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1308016
Identifier Type: -
Identifier Source: org_study_id
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