Re-Induction Therapy for Relapsed Pediatric T-Cell Acute Lymphoblastic Leukemia or Lymphoma

NCT ID: NCT02518750

Last Updated: 2019-04-03

Basic Information

• Recruitment Status: TERMINATED
• Clinical Phase: PHASE2
• Total Enrollment: 3 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2016-11-23
• Study Completion Date: 2018-03-11

Brief Summary

This is a phase-II study to evaluate the efficacy of a salvage regimen in children with relapsed T-cell ALL or lymphoma. Peg-asparaginase, mitoxantrone, intrathecal triples (IT) (intrathecal methotrexate/hydrocortisone/cytarabine) (ITMHA) and dexamethasone are commonly used drugs to treat relapsed or refractory acute lymphocytic leukemia or lymphoma (ALL). In this study, the investigators want to know if adding three drugs called panobinostat, bortezomib and liposomal vincristine (VSLI) to this regimen will result in remission (no signs or symptoms of leukemia or lymphoma).

• Panobinostat has been approved by the FDA for treating adults with multiple myeloma, but it has not been approved for use in children and has not been given together with the other drugs used in this study. It has not been widely studied in children.
• VSLI has been approved by the FDA for adults with relapsed or refractory ALL, but has not yet been approved for treating children with leukemia or lymphoma.
• Bortezomib has been approved by the FDA for treating adults with a cancer called multiple myeloma and adults with relapsed mantle cell lymphoma; it has not been approved for treating children.

PRIMARY OBJECTIVE:

• To estimate the complete remission (CR) rate for patients with T-cell lymphoblastic leukemia and lymphoma in first relapse.

SECONDARY OBJECTIVES:

• To evaluate minimal residual disease (MRD) levels at end of each block of therapy.
• To describe the toxicities of vincristine sulfate liposome injection (VSLI) when used in combination with chemotherapy and bortezomib.

Detailed Description

This is a study of re-induction therapy that will comprise of three blocks of multi-agent chemotherapy. CR will be evaluated following each block of therapy. All patients will be candidates for hematopoietic stem cell transplant (HSCT) once they achieve negative minimal residual disease (MRD). If patients cannot proceed to HSCT following Block A, they will continue therapy on Block B and Block C until ready for HSCT.

Three Block Induction:

Block A: approximately 5 weeks

• Dexamethasone 10 mg/m^2/day orally (PO) Days 1-8, 15-22 (Total 16 days)
• Panobinostat 24 mg/m^2/dose PO Day 2,4,6
• Liposomal vincristine (VSLI) 2.25 mg/m^2 no cap intravenously (IV) on Days 7, 14, 21, 28
• Mitoxantrone 10 mg/m^2 IV Day 7,14 (In the absence of peripheral blasts, Day 14 Mitoxantrone will be given if WBC ≥1000 and ANC ≥300)
• Peg-asparaginase 2500 units/m^2 on Days 9,23
• Bortezomib 1.3 mg/m^2 IV Days 16, 19, 23, 26
• Intrathecal Triples (IT) (intrathecal methotrexate/hydrocortisone/cytarabine) (ITMHA) Days 1, 7, 14, 21, 28. Additional ITs on Days 10 and 17 for patients with central nervous system (CNS) 2, 3 or traumatic tap with blasts

Block B: approximately 5 weeks

• High-dose methotrexate 8 g/m^2 IV over 24 hours (will not be given to patients with prior cranial irradiation) Day 1
• 6-mercaptopurine 50 mg/m^2 PO days 1-14
• ITMHA Day 1
• High-dose cytarabine 3 g/m^2 IV every 12 hours (Q12H) Days 15 and 16

Block C: approximately 3 weeks

• Nelarabine 650 mg/m^2/day IV Days 1-5 (Clofarabine 40 mg/m^2/day IV Days 1-5 will be given instead of nelarabine for patients with B-lymphoblastic leukemia and lymphoma in stratum II)
• Cyclophosphamide 300 mg/m^2 IV Days 1-5
• Etoposide 100 mg/m^2/day IV Days 1-5

Response evaluation is performed after the end of each treatment block. All patients should proceed to hematopoietic stem cell transplantation (HSCT) after achieving negative minimal residual disease (MRD) when a suitable donor is identified. Patients could continue on Block B and Block C if not ready for HSCT. If after completion of Block C, MRD is persistently positive, the plan will be discussed with the principal investigator and co-principal investigator and the transplant team. Enrollment on ongoing natural killer (NK) cell studies will be considered. For patients who require a second transplant, HAP3R (another clinical trial at St. Jude Children's Research Hospital) may be an option. Donor will be selected according to institutional practices and transplant regimens will be used according to institutional HSCT protocols and guidelines.

Conditions

Acute Lymphoblastic Leukemia; Lymphoma, Non-Hodgkin's; Leukemia, T-Cell; Leukemia, B-Cell

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Study Participants

Participants with ALL will receive the following interventions in three treatment blocks:

• Block A: Dexamethasone, panobinostat, liposomal vincristine, mitoxantrone, peg-asparaginase, bortezomib, intrathecal triples.
• Block B: High-dose methotrexate, 6-mercaptopurine, intrathecal triples, high-dose cytarabine.
• Block C: Nelarabine or clofarabine, cyclophosphamide, etoposide.

Group Type: EXPERIMENTAL

Dexamethasone

Intervention Type: DRUG

Given orally (PO).

Panobinostat

Intervention Type: DRUG

Given PO.

Liposomal vincristine

Intervention Type: DRUG

For intravenous (IV) use only.

Mitoxantrone

Intervention Type: DRUG

Given IV.

Peg-asparaginase

Intervention Type: DRUG

Given IV or intramuscularly (IM).

In case of allergy or intolerance to Peg-asparaginase, Erwinia L-asparaginase (Erwinase®) will be used. Erwinia L-asparaginase is given by either IV or IM injection.

Bortezomib

Intervention Type: DRUG

Given by IV push over 3 to 5 seconds. For IV use only.

Intrathecal Triples

Intervention Type: DRUG

Given IT as ITMHA.

High-dose methotrexate

Intervention Type: DRUG

Given intrathecally (IT) or IV.

6-Mercaptopurine

Intervention Type: DRUG

Given PO at consistent time each day.

High-dose cytarabine

Intervention Type: DRUG

Given IT or IV.

Nelarabine

Intervention Type: DRUG

Given IV

Cyclophosphamide

Intervention Type: DRUG

Given IV.

Etoposide

Intervention Type: DRUG

Given IV.

In case of etoposide reactions, IV etoposide phosphate (Etopophos®) will be used.

Clofarabine

Intervention Type: DRUG

Given IV.

Clofarabine will be given instead of nelarabine for patients with B-lymphoblastic leukemia and lymphoma in stratum II.

Interventions

Dexamethasone

Given orally (PO).

Intervention Type: DRUG

Panobinostat

Given PO.

Intervention Type: DRUG

Liposomal vincristine

For intravenous (IV) use only.

Intervention Type: DRUG

Mitoxantrone

Given IV.

Intervention Type: DRUG

Peg-asparaginase

Given IV or intramuscularly (IM).

In case of allergy or intolerance to Peg-asparaginase, Erwinia L-asparaginase (Erwinase®) will be used. Erwinia L-asparaginase is given by either IV or IM injection.

Intervention Type: DRUG

Bortezomib

Given by IV push over 3 to 5 seconds. For IV use only.

Intervention Type: DRUG

Intrathecal Triples

Given IT as ITMHA.

Intervention Type: DRUG

High-dose methotrexate

Given intrathecally (IT) or IV.

Intervention Type: DRUG

6-Mercaptopurine

Given PO at consistent time each day.

Intervention Type: DRUG

High-dose cytarabine

Given IT or IV.

Intervention Type: DRUG

Nelarabine

Given IV

Intervention Type: DRUG

Cyclophosphamide

Given IV.

Intervention Type: DRUG

Etoposide

Given IV.

In case of etoposide reactions, IV etoposide phosphate (Etopophos®) will be used.

Intervention Type: DRUG

Clofarabine

Given IV.

Clofarabine will be given instead of nelarabine for patients with B-lymphoblastic leukemia and lymphoma in stratum II.

Intervention Type: DRUG

Other Intervention Names

Decadron®; LBH589; Vincristine sulfate liposome injection; VSLI; Marqibo®; Novantrone®; Peg-L-asparaginase; Pegaspargase; Oncaspar®; Velcade; MLN341; LDP-341; ITMHA; Methotrexate/Hydrocortisone/Cytarabine; HDMTX; 6-MP; Purinethol®; Ara-C; Cytosar-U®; Arranon®; Compound 506U78; Cytoxan®; VP-16; Vepesid®; Clolar™; Clofarex

Eligibility Criteria

Inclusion Criteria

• Participants must have relapsed or refractory acute lymphoblastic leukemia or lymphoma (ALL):

• Stratum I: T-cell lymphoblastic leukemia or lymphoma in first relapse or refractory to one or two courses of frontline induction therapy.
• Stratum II: B-cell or T-cell lymphoblastic leukemia or lymphoma in second or third relapse or refractory to 2 or 3 induction or re-induction attempts. Patients with Ph+ ALL must be refractory or relapsed after treatment with regimen that included a tyrosine kinase inhibitor (TKI).
• Relapse in ALL is defined as the reappearance (in a patient who has previously achieved remission) of leukemic blasts in the bone marrow.

• Should flow cytometric analyses suggest relapse (by the reappearance of a similar immunophenotype to the original leukemia) in the presence of <5% blasts morphologically, a repeat bone marrow test is recommended to confirm relapse.
• Molecular or genetic relapse is characterized by the reappearance of a cytogenetic or molecular abnormality.
• Age is ≤ 21 years (participant has not yet reached 22nd birthday).
• Able to swallow capsules.
• Karnofsky or Lansky performance score is ≥ 60%. The Lansky performance score should be used for participants < 16 years and the Karnofsky performance score for participants ≥ 16 years.
• Prior therapy:

• There is no waiting period for participants who relapse while receiving therapy if they are free from side effects attributable to such therapy.
• Emergent radiation therapy, one dose of intrathecal chemotherapy and up to 7 days of steroids or hydroxyurea are permitted before start of treatment in participants who relapse after completion of frontline therapy. Other circumstances must be cleared by PI or medical designee.
• At least 90 days have elapsed since bone marrow transplant and participant is off immune suppression for ≥ 2 weeks, if applicable.
• Adequate renal function defined as glomerular filtration rate ≥ 60 cc/min/1.73m^2 or serum creatinine based on age as follows:

• If age is 1 to 2 years, then maximum serum creatinine (mg/dL) is 0.6 for males or females.
• If age is 2 to 6 years, then maximum serum creatinine (mg/dL) is 0.8 for males or females.
• If age is 6 to 10 years, then maximum serum creatinine (mg/dL) is 1 for males or females.
• If age is 10 to <13 years, then maximum serum creatinine (mg/dL) is 1.2 for males or females.
• If age is 13 to 16 years, then maximum serum creatinine (mg/dl) is 1.5 for males or 1.4 for females.
• If age is > 16 years, then maximum serum creatinine (mg/dl) is 1.7 for males or 1.4 for females.
• Adequate hepatic function defined as:

• Direct bilirubin ≤ 1.4 mg/dL (if total bilirubin > 1.4 mg/dL) AND
• AST and ALT < 5 x ULN for age.
• Adequate cardiac function defined as shortening fraction of ≥ 27% or ejection fraction ≥ 45%.
• Lymphoma participants without bone marrow involvement must have:

• Absolute neutrophil count (ANC) >1,000/mm3, AND
• Platelet count ≥50,000/mm^3 (without transfusion support)
• NOTE: These criteria are waived for participants with leukemia or lymphoma participants with bone marrow involvement.
• Written, informed consent and assent following Institutional Review Board, NCI, FDA and OHRP guidelines.

Exclusion Criteria

• Prior histone deacytylases (HDAC), DAC, HSP90 inhibitors or valproic acid for treatment of cancer.
• Patients who will need valproic acid for any medical condition during the study or within 5 days prior to first panobinostat treatment.
• Impaired cardiac function or clinically significant cardiac diseases, history of arrhythmia (including ventricular fibrillation or torsade de pointes), bradycardia <50 bpm, screening ECG with prolonged QTc or uncontrolled hypertension.
• Impairment of gastrointestinal (GI) function or GI disease that may significantly alter the absorption of panobinostat.
• Patients with diarrhea > CTCAE grade 2.
• Other concurrent severe and/or uncontrolled medical conditions (e.g., uncontrolled diabetes or active or uncontrolled infection) including abnormal laboratory values, that could cause unacceptable safety risks or compromise compliance with the protocol.
• Patients using medications that have a relative risk of prolonging the QT interval or inducing torsade de pointes if treatment cannot be discontinued or switched to a different medication prior to starting treatment.
• Patients who have received targeted agents within 2 weeks or within 5 half-lives of the agent and active metabolites (whichever is longer) and who have not recovered from side effects of those therapies.
• Patients who have undergone major surgery ≤ 4 weeks prior to starting treatment or who have not recovered from side effects of such therapy.
• Patients with known positivity for human immunodeficiency virus (HIV) or hepatitis B/C.
• Inability to swallow capsules.
• Active, uncontrolled infection or severe concurrent medical disease, including but not limited to congestive heart failure, cardiac arrhythmias, or psychiatric illness.
• Isolated extramedullary relapse (leukemia) or isolated CNS lymphoma.
• Pregnant or lactating (female participant of childbearing potential must have negative serum or urine pregnancy test required within 7 days prior to start of treatment). Male or female of reproductive potential has agreed to use effective contraception method for duration of study treatment.
• Down syndrome.
• Inability or unwillingness or research participant or legal guardian/representative to give written informed consent.

• Maximum Eligible Age: 21 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Novartis Pharmaceuticals

INDUSTRY

Sponsor Role: collaborator

Spectrum Pharmaceuticals, Inc

INDUSTRY

Sponsor Role: collaborator

St. Jude Children's Research Hospital

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Sima Jeha, MD

Role: PRINCIPAL_INVESTIGATOR

St. Jude Children's Research Hospital

Locations

St. Jude Children's Research Hospital

Memphis, Tennessee, United States

Countries

United States

Provided Documents

Document Type: Study Protocol and Statistical Analysis Plan

View Document

Related Links

http://www.stjude.org

St. Jude Children's Research Hospital

http://www.stjude.org/protocols

Clinical Trials Open at St. Jude

Other Identifiers

NCI-2015-00935

Identifier Type: REGISTRY

Identifier Source: secondary_id

TSALV

Identifier Type: -

Identifier Source: org_study_id