Improving the Detection of Active Tuberculosis in Accident and Emergency Departments

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

1000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-05-31

Study Completion Date

2017-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Tuberculosis (TB) control remains a public health challenge. Many people in the UK do not have a general practitioner (GP) registration and their only interaction with the NHS is via Accident and Emergency (A\&E) Departments of hospitals. This is often the case for those in hard to reach groups, who are also those often at highest risk of TB. This study seeks to assess whether A\&E Departments are effective sites for the identification and onward management of TB, both in its latent and active forms.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Testing for Tuberculosis in the United Kingdom HIV Infected Population

NCT02712671

HIV Latent Tuberculosis

UNKNOWN

Effectiveness of Active Case Finding of Household Contacts in a Routine Tuberculosis (TB) Control Program

NCT02174380

Tuberculosis

UNKNOWN NA

Point-of-care Triage Test for Active Tuberculosis

NCT04232618

Tuberculosis Tuberculosis, Pulmonary

UNKNOWN

Can Screening People Registering With Primary Care Improve the Detection of Tuberculosis?

NCT00214708

Tuberculosis

WITHDRAWN

Early Diagnosis of Active Tuberculosis Using Ultra Low-dose Chest CT

NCT03220464

Tuberculosis, Pulmonary Latent Tuberculosis

UNKNOWN NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

This proposal is focused upon early diagnosis, referral and treatment of active tuberculosis, which has two key components: 1) ensuring optimal outcome for individuals; 2) contributing to disease control in public health terms by preventing further spread.

A\&E Departments are an important point of testing and referral for the client group that constitute those at greatest risk, as for many this will be their only interaction with the health service. Currently, A\&E Departments contribute about 20% of those diagnosed with TB. The majority of these individuals are most likely to have presented with symptoms indicative of disease, compared to those attending for other reasons who would have been unlikely to have been tested or referred.

This study will seek to evaluate specific measures currently being undertaken by Public Health England and the NHS to control TB as well as investigate whether case finding for active TB in A\&E departments would improve TB control. The economic impact of these interventions will be evaluated, providing a measure of its value for money.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Latent Tuberculosis Active Tuberculosis

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

high risk TB individuals attending A&E Departments

Assessment against inclusion/exclusion criteria in terms of risk of TB. If eligible, assessment and testing as appropriate for active or latent TB

venepuncture, sputum collection, xray

Intervention Type PROCEDURE

venepuncture, sputum collection, xray

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

venepuncture, sputum collection, xray

Intervention Type PROCEDURE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

1. Individuals 16 years or older, who are new entrants from high incidence countries who have arrived in the UK within the past 2 years or those born in high incidence countries who entered the UK more than five years ago, but have spent more than one year (cumulative) in the past five years in a high incidence country.
2. Those with social risk factors who have signs and/or symptoms of TB.