Clinical Trial of Pulmonary Cryptococcosis in China

NCT ID: NCT02503449

Last Updated: 2015-07-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

260 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-12-31

Study Completion Date

2017-12-31

Brief Summary

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The purpose of the study:1.Improve the understanding of the risk factors of pulmonary cryptococcosis;2.Improve the awareness of pulmonary cryptococcosis clinical and imaging manifestations;3.Grasp pulmonary cryptococcosis patients of clinical and imaging manifestations in different conditions;4.Learn about antibacterial activity of antifungal drugs for cryptococcosis in China.

Detailed Description

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1. Patients corresponding to inclusion criteria and obtaining informed consent are included in the research in department of respiration ward in cooperative hospitals.
2. Relevant case report forms are created in this study.
3. Basic information such as age,weight and height is recorded in selected cases.Clinical manifestations,risk factors,laboratory examination,imaging examination,etiological examination and histopathological examination are also recorded in selected cases by case report forms.In addition,antifungal treatment is recorded including name,dose,time of starting treatment and terminate treatment.Causes of terminate treatment and curative effect evaluation should be analysed.
4. Statistical analysis.

Conditions

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Cryptococcosis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

Patients possess clinical or imaging manifestations of pulmonary infections,with any of the results(by one of following conditions) by microbiological examination or histopathologic examination

1. Cryptococcal capsular polysaccharide antigen of blood or pleural effusion is positive
2. Cryptococcus(fungus culture) is discovered by lower respiratory tract specimens
3. Cryptococcus(pleural effusions culture) is discovered by pleural effusions collected under sterile condition
4. Cryptococcus(pus culture) is discovered by pus smear out of pulmonary infections in disseminated infection patients
5. Cryptococcus(blood culture) is discovered by microscopy of specimens of blood smear
6. Cryptococcus is discovered by culturing of the pathological tissue specimens in aseptic condition
7. Cryptococcal capsular budding yeast with inflammatory reaction is discovered by histopathological examination,cell pathology examination or microscopic examination in aseptic condition

Exclusion Criteria

1. Patients suffer from acquired immune deficiency syndrome
2. Patients or their legal guardians request to withdraw the clinical research
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Chinese PLA General Hospital

OTHER

Sponsor Role collaborator

Beijing Chao Yang Hospital

OTHER

Sponsor Role collaborator

Ministry of Health, China

OTHER_GOV

Sponsor Role collaborator

Peking University Third Hospital

OTHER

Sponsor Role collaborator

Tianjin Medical University General Hospital

OTHER

Sponsor Role collaborator

First Hospital of China Medical University

OTHER

Sponsor Role collaborator

Shengjing Hospital

OTHER

Sponsor Role collaborator

Second Hospital of Jilin University

OTHER

Sponsor Role collaborator

Shandong Provincial Hospital

OTHER_GOV

Sponsor Role collaborator

Huadong Hospital

OTHER

Sponsor Role collaborator

Nanjing PLA General Hospital

OTHER

Sponsor Role collaborator

Fuzhou General Hospital

OTHER

Sponsor Role collaborator

Guangzhou Institute of Respiratory Disease

OTHER

Sponsor Role collaborator

Wuhan TongJi Hospital

OTHER

Sponsor Role collaborator

Xi'an Jiaotong University

OTHER

Sponsor Role collaborator

Guizhou Provincial People's Hospital

OTHER

Sponsor Role collaborator

Shenyang Military General Hospital

UNKNOWN

Sponsor Role collaborator

The Second Hospital of Hebei Medical University

OTHER

Sponsor Role collaborator

Xiangya Hospital of Central South University

OTHER

Sponsor Role collaborator

Fujian Provincial Hospital

OTHER

Sponsor Role collaborator

Fuzhou Pulmonary Hospital of Fujian

OTHER

Sponsor Role collaborator

Southwest Hospital, China

OTHER

Sponsor Role collaborator

First Affiliated Hospital of Zhejiang University

OTHER

Sponsor Role collaborator

Wenzhou Medical University

OTHER

Sponsor Role collaborator

Shanghai Zhongshan Hospital

OTHER

Sponsor Role collaborator

The First Affiliated Hospital of Nanchang University

OTHER

Sponsor Role collaborator

Longyan City First Hospital

OTHER

Sponsor Role collaborator

Zhixin Liang

OTHER

Sponsor Role lead

Responsible Party

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Zhixin Liang

Chinese Medical Association of respiratory diseases

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Zhixin Liang, Doctor

Role: STUDY_DIRECTOR

Chinese PLA General Hospital

Zhen Wang

Role: PRINCIPAL_INVESTIGATOR

Beijing Chao Yang Hospital

Yanming Li

Role: PRINCIPAL_INVESTIGATOR

Ministry of Health, China

Lina Sun

Role: PRINCIPAL_INVESTIGATOR

Peking University Third Hospital

Jie Cao

Role: PRINCIPAL_INVESTIGATOR

Tianjin Medical University General Hospital

Yunzhuo Chu

Role: PRINCIPAL_INVESTIGATOR

First Hospital of China Medical University

Zhijie Zhang

Role: PRINCIPAL_INVESTIGATOR

Shengjing Hospital

Yufen Jin

Role: PRINCIPAL_INVESTIGATOR

Second Hospital of Jilin University

Xiaobin Ma

Role: PRINCIPAL_INVESTIGATOR

Shandong Provincial Hospital

Yanping Zhu

Role: PRINCIPAL_INVESTIGATOR

Huadong Hospital

Xin Su

Role: PRINCIPAL_INVESTIGATOR

Nanjing PLA General Hospital

Guoxiang Lai

Role: PRINCIPAL_INVESTIGATOR

Fuzhou General Hospital

Feng Ye

Role: PRINCIPAL_INVESTIGATOR

Guangzhou Institute of Respiratory Disease

Shengdao Xiong

Role: PRINCIPAL_INVESTIGATOR

Wuhan TongJi Hospital

Lan Yang

Role: PRINCIPAL_INVESTIGATOR

Xi'an Jiaotong University

Hong Yu

Role: PRINCIPAL_INVESTIGATOR

Guizhou Provincial People's Hospital

wencheng Xue

Role: PRINCIPAL_INVESTIGATOR

Shenyang Military General Hospital

Yadong Yuan

Role: PRINCIPAL_INVESTIGATOR

The Second Hospital of Hebei Medical University

Chengping Hu

Role: PRINCIPAL_INVESTIGATOR

Xiangya Hospital of Central South University

Baosong Xie

Role: PRINCIPAL_INVESTIGATOR

Fujian Provincial Hospital

Xiaohong Chen

Role: PRINCIPAL_INVESTIGATOR

Fuzhou Pulmonary Hospital of Fujian

Xiangdong Zhou

Role: PRINCIPAL_INVESTIGATOR

Southwest Hospital, China

Wenjiang Ma

Role: PRINCIPAL_INVESTIGATOR

First Affiliated Hospital of Zhejiang University

Yuping Li

Role: PRINCIPAL_INVESTIGATOR

Wenzhou Medical University

Hongni Jiang

Role: PRINCIPAL_INVESTIGATOR

Shanghai Zhongshan Hospital

Wei Bai

Role: PRINCIPAL_INVESTIGATOR

The First Affiliated Hospital of Nanchang University

Sucheng Zhong

Role: PRINCIPAL_INVESTIGATOR

Longyan City First Hospital

Other Identifiers

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LYN-316

Identifier Type: -

Identifier Source: org_study_id

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